Technology Process of 3-[2-(2,6-difluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-6-yl)-benzamide
There total 18 articles about 3-[2-(2,6-difluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-6-yl)-benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-[2-(2,6-difluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide;
With
sodium hydroxide;
In
tetrahydrofuran;
at 20 ℃;
for 15h;
With
hydrogenchloride;
In
water;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 0 - 20 °C
2.1: potassium hydroxide; methanol / 12 h / 100 °C
3.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C
3.2: 3 h / 0 °C
4.1: tribromide phosphate / tetrahydrofuran / 12 h / 0 - 20 °C
5.1: 3 h / 160 °C
6.1: potassium hydroxide / 18-crown-6 ether / dichloromethane / 16 h / 20 °C
7.1: hydrogen / palladium on activated charcoal / methanol / 24 h / 20 °C
8.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 24 h / 20 °C
8.2: 24 h / 20 °C
9.1: sodium hydroxide / tetrahydrofuran / 15 h / 20 °C
With
methanol; borane-THF; oxalyl dichloride; di-isopropyl azodicarboxylate; tribromide phosphate; hydrogen; triphenylphosphine; potassium hydroxide; sodium hydroxide;
18-crown-6 ether; palladium on activated charcoal; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: tribromo phosphate / tetrahydrofuran / 12 h / 0 - 20 °C
2.1: 3 h / 160 °C
3.1: potassium hydroxide / 18-crown-6 ether / dichloromethane / 16 h / 20 °C
4.1: hydrogen / palladium on activated charcoal / methanol / 24 h / 20 °C
5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 24 h / 20 °C
5.2: 24 h / 20 °C
6.1: sodium hydroxide / tetrahydrofuran / 15 h / 20 °C
With
oxalyl dichloride; tribromo phosphate; hydrogen; potassium hydroxide; sodium hydroxide;
18-crown-6 ether; palladium on activated charcoal; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; dichloromethane;
![3-[2-(2,6-difluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide](/Databaselist/images/loading.webp)
