3-[2-(2,6-difluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-6-yl)-benzamide

Base Information

Chemical Name:3-[2-(2,6-difluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-6-yl)-benzamide
CAS No.:1282520-39-1
Molecular Formula:C₂₅H₂₄F₂N₂O₅
Molecular Weight:470.473
Hs Code.:

Synonyms:3-[2-(2,6-difluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-6-yl)-benzamide

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Chemical Property of 3-[2-(2,6-difluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-6-yl)-benzamide

Chemical Property:

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Technology Process of 3-[2-(2,6-difluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-6-yl)-benzamide

There total 18 articles about 3-[2-(2,6-difluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-6-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1282521-25-8
3-[2-(2,6-difluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide

: 1282520-39-1
3-[2-(2,6-difluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-6-yl)-benzamide

Guidance literature:: 3-[2-(2,6-difluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide; With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 15h;

With hydrogenchloride; In water;

Reference yield:

: 13036-02-7
Dimethyl 5-hydroxyisophthalate

: 1282520-39-1
3-[2-(2,6-difluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 0 - 20 °C

2.1: potassium hydroxide; methanol / 12 h / 100 °C

3.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C

3.2: 3 h / 0 °C

4.1: tribromide phosphate / tetrahydrofuran / 12 h / 0 - 20 °C

5.1: 3 h / 160 °C

6.1: potassium hydroxide / 18-crown-6 ether / dichloromethane / 16 h / 20 °C

7.1: hydrogen / palladium on activated charcoal / methanol / 24 h / 20 °C

8.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 24 h / 20 °C

8.2: 24 h / 20 °C

9.1: sodium hydroxide / tetrahydrofuran / 15 h / 20 °C

With methanol; borane-THF; oxalyl dichloride; di-isopropyl azodicarboxylate; tribromide phosphate; hydrogen; triphenylphosphine; potassium hydroxide; sodium hydroxide; 18-crown-6 ether; palladium on activated charcoal; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1282520-98-2
dimethyl 5-hydroxy isophthalate

: 1282520-39-1
3-[2-(2,6-difluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: tribromo phosphate / tetrahydrofuran / 12 h / 0 - 20 °C

2.1: 3 h / 160 °C

3.1: potassium hydroxide / 18-crown-6 ether / dichloromethane / 16 h / 20 °C

4.1: hydrogen / palladium on activated charcoal / methanol / 24 h / 20 °C

5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 24 h / 20 °C

5.2: 24 h / 20 °C

6.1: sodium hydroxide / tetrahydrofuran / 15 h / 20 °C

With oxalyl dichloride; tribromo phosphate; hydrogen; potassium hydroxide; sodium hydroxide; 18-crown-6 ether; palladium on activated charcoal; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane;