(R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-4-methoxybutanamide

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Chemical Name:(R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-4-methoxybutanamide
CAS No.:1035040-11-9
Molecular Formula:C₂₇H₃₃ClN₄O₃
Molecular Weight:497.037
Hs Code.:

Synonyms:(R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-4-methoxybutanamide

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Chemical Property of (R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-4-methoxybutanamide

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Technology Process of (R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-4-methoxybutanamide

There total 3 articles about (R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-4-methoxybutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 29006-02-8
4-methoxybutyric acid

: 1035042-01-3
(R)-2-((1-(2-aminoethyl)pyrrolidin-2-yl)methyl)-4-(4-chlorobenzyl)phthalazin-1(2H)-one

: 1035040-11-9
(R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-4-methoxybutanamide

Guidance literature:: With ammonia; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1035041-98-5
(R)-2-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)isoindoline-1,3-dione

: 1035040-11-9
(R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-4-methoxybutanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrazine hydrate / ethanol / 1.25 h / 80 °C

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrazine hydrate; triethylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.7b00112

Reference yield:

: 955359-79-2
4-[(4-chlorophenyl)methyl]-2-{[(2R)-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone

: 1035040-11-9
(R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-4-methoxybutanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / butanone / 114 h / 20 - 80 °C / Inert atmosphere

2.1: hydrazine hydrate / ethanol / 1.25 h / 80 °C

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

With potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrazine hydrate; triethylamine; In ethanol; N,N-dimethyl-formamide; butanone;
DOI:10.1021/acsmedchemlett.7b00112