Technology Process of 16β-(4-phenyl-1H-1,2,3-triazol-1-ylmethyl)androst-5-ene-3β,17β-diol
There total 6 articles about 16β-(4-phenyl-1H-1,2,3-triazol-1-ylmethyl)androst-5-ene-3β,17β-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: pyridine
2: potassium borohydride; acetic acid / methanol; ethanol / pH 6 - 8
3: pyridine
4: sodium azide / N,N-dimethyl-formamide / 6 h / 70 °C
5: sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; copper(ll) sulfate pentahydrate / dichloromethane; water / 20 °C
6: methanol; potassium hydroxide / 1 h / 50 °C
With
pyridine; methanol; sodium azide; copper(ll) sulfate pentahydrate; potassium borohydride; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; acetic acid; potassium hydroxide;
In
methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
5: Huisgen 1,3-dipolar cycloaddition;
DOI:10.3390/molecules16064786
- Guidance literature:
-
Multi-step reaction with 4 steps
1: pyridine
2: sodium azide / N,N-dimethyl-formamide / 6 h / 70 °C
3: sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; copper(ll) sulfate pentahydrate / dichloromethane; water / 20 °C
4: methanol; potassium hydroxide / 1 h / 50 °C
With
pyridine; methanol; sodium azide; copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; potassium hydroxide;
In
dichloromethane; water; N,N-dimethyl-formamide;
3: Huisgen 1,3-dipolar cycloaddition;
DOI:10.3390/molecules16064786
