adamantane carboxylic acid N-[2-(4-benzyl-1-piperazinyl)ethyl]-N-methylcarboxamide

Base Information

Chemical Name:adamantane carboxylic acid N-[2-(4-benzyl-1-piperazinyl)ethyl]-N-methylcarboxamide
CAS No.:256352-20-2
Molecular Formula:C₂₅H₃₇N₃O
Molecular Weight:395.588
Hs Code.:

Synonyms:adamantane carboxylic acid N-[2-(4-benzyl-1-piperazinyl)ethyl]-N-methylcarboxamide

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Chemical Property of adamantane carboxylic acid N-[2-(4-benzyl-1-piperazinyl)ethyl]-N-methylcarboxamide

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Technology Process of adamantane carboxylic acid N-[2-(4-benzyl-1-piperazinyl)ethyl]-N-methylcarboxamide

There total 3 articles about adamantane carboxylic acid N-[2-(4-benzyl-1-piperazinyl)ethyl]-N-methylcarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 2094-72-6
1-Adamantanecarbonyl chloride

: 157368-33-7
2-(4-benzyl-1-piperazinyl)ethylmethylamine

: 256352-20-2
adamantane carboxylic acid N-[2-(4-benzyl-1-piperazinyl)ethyl]-N-methylcarboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm9806704

Reference yield:

: 2759-28-6
1-phenylmethylpiperazine

: 256352-20-2
adamantane carboxylic acid N-[2-(4-benzyl-1-piperazinyl)ethyl]-N-methylcarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: dimethylformamide; tetrahydrofuran / 48 h / 70 °C

2: 82 percent / lithium aluminum hydride / tetrahydrofuran / Heating

3: 94 percent / Et₃N / CH₂Cl₂ / 20 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: Condensation / 2: Reduction / 3: Condensation;
DOI:10.1021/jm9806704

Reference yield:

: 256352-19-9
2-(4-benzyl-1-piperazinyl)-N-methylacetamide

: 256352-20-2
adamantane carboxylic acid N-[2-(4-benzyl-1-piperazinyl)ethyl]-N-methylcarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / lithium aluminum hydride / tetrahydrofuran / Heating

2: 94 percent / Et₃N / CH₂Cl₂ / 20 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane; 1: Reduction / 2: Condensation;
DOI:10.1021/jm9806704