Technology Process of ethyl (2R,3R,4R,5R)-5-azido-4,6-bis(benzyloxy)-2,3-dihydroxyhexanoate
There total 3 articles about ethyl (2R,3R,4R,5R)-5-azido-4,6-bis(benzyloxy)-2,3-dihydroxyhexanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
osmium(VIII) oxide; methanesulfonamide; sodium hydrogencarbonate; hydroquinidein 1,4-phthalazinediyl diether;
In
water; toluene; tert-butyl alcohol;
at 0 ℃;
for 72h;
Reagent/catalyst;
Concentration;
Overall yield = 78 %; diastereoselective reaction;
DOI:10.3998/ark.5550190.0013.925
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium periodate / water; acetonitrile / 0.67 h / 20 °C
2: lithium chloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 20 °C / Inert atmosphere
3: methanesulfonamide / water; tert-butyl alcohol / 120 h / 0 °C
With
sodium periodate; methanesulfonamide; N-ethyl-N,N-diisopropylamine; lithium chloride;
In
water; acetonitrile; tert-butyl alcohol;
2: |Wittig Olefination / 3: |Sharpless Dihydroxylation;
DOI:10.3998/ark.5550190.0013.925
- Guidance literature:
-
Multi-step reaction with 2 steps
1: lithium chloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 20 °C / Inert atmosphere
2: methanesulfonamide / water; tert-butyl alcohol / 120 h / 0 °C
With
methanesulfonamide; N-ethyl-N,N-diisopropylamine; lithium chloride;
In
water; acetonitrile; tert-butyl alcohol;
1: |Wittig Olefination / 2: |Sharpless Dihydroxylation;
DOI:10.3998/ark.5550190.0013.925
