(3S,5R)-3-[3-(tert-butoxy-carbonyl)-aminopropyl]-5-phenylmethyl-2-oxopiperazine

Base Information

Chemical Name:(3S,5R)-3-[3-(tert-butoxy-carbonyl)-aminopropyl]-5-phenylmethyl-2-oxopiperazine
CAS No.:1408237-97-7
Molecular Formula:C₁₉H₂₉N₃O₃
Molecular Weight:347.458
Hs Code.:

Synonyms:(3S,5R)-3-[3-(tert-butoxy-carbonyl)-aminopropyl]-5-phenylmethyl-2-oxopiperazine

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Chemical Property of (3S,5R)-3-[3-(tert-butoxy-carbonyl)-aminopropyl]-5-phenylmethyl-2-oxopiperazine

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Technology Process of (3S,5R)-3-[3-(tert-butoxy-carbonyl)-aminopropyl]-5-phenylmethyl-2-oxopiperazine

There total 4 articles about (3S,5R)-3-[3-(tert-butoxy-carbonyl)-aminopropyl]-5-phenylmethyl-2-oxopiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1408237-95-5
(S)-methyl 5-[(tert-butoxycarbonyl)amino]-2-[((R)-1-cyano-2-phenylethyl)amino]-pentanoate

: 1408237-97-7
(3S,5R)-3-[3-(tert-butoxy-carbonyl)-aminopropyl]-5-phenylmethyl-2-oxopiperazine

Guidance literature:: With 10% Pd/C; hydrogen; In methanol; at 20 ℃; for 24h; under 760.051 Torr;
DOI:10.1016/j.tetasy.2012.07.009

Reference yield:

: (2S)-2-amino-5-[(tert-butoxycarbonyl)amino]pentanoic acid methylester hydrochloride

: 1408237-97-7
(3S,5R)-3-[3-(tert-butoxy-carbonyl)-aminopropyl]-5-phenylmethyl-2-oxopiperazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0.25 h / 20 °C

1.2: 1 h / -20 °C

2.1: dichloromethane / 0 °C

3.1: 10% Pd/C; hydrogen / methanol / 24 h / 20 °C / 760.05 Torr

With 10% Pd/C; hydrogen; triethylamine; In methanol; dichloromethane; 2.1: |Strecker Aminoacid Synthesis;
DOI:10.1016/j.tetasy.2012.07.009

Reference yield:

: 122-78-1
phenylacetaldehyde

: 1408237-97-7
(3S,5R)-3-[3-(tert-butoxy-carbonyl)-aminopropyl]-5-phenylmethyl-2-oxopiperazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0.25 h / 20 °C

1.2: 1 h / -20 °C

2.1: dichloromethane / 0 °C

3.1: 10% Pd/C; hydrogen / methanol / 24 h / 20 °C / 760.05 Torr

With 10% Pd/C; hydrogen; triethylamine; In methanol; dichloromethane; 2.1: |Strecker Aminoacid Synthesis;
DOI:10.1016/j.tetasy.2012.07.009