C₅₉H₇₂N₈O₁₁

Base Information

• Chemical Name: C₅₉H₇₂N₈O₁₁
• CAS No.: 872043-66-8
• Molecular Formula: C₅₉H₇₂N₈O₁₁
• Molecular Weight: 1069.27
• Mol file: 872043-66-8.mol

Synonyms:C₅₉H₇₂N₈O₁₁

Chemical Property of C₅₉H₇₂N₈O₁₁

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₉H₇₂N₈O₁₁

There total 4 articles about C₅₉H₇₂N₈O₁₁ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-2,6-dimethyl-phenyl)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid + 3,6-bis(aminomethyl)-5-methyl-1,2-dihydropyrazin-2-one (501022-75-9) → C59H72N8O11 (872043-66-8)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

DOI:10.1021/jm050377l

Reference yield:

3,6-bis(benzyloxycarbonylaminomethyl)-5-methyl-1,2-dihydropyrazin-2-one (501022-57-7) → C59H72N8O11 (872043-66-8)

Guidance literature:

Multi-step reaction with 2 steps

1: HBr; AcOH / 3 h / 20 °C

2: 144 mg / DIPEA; PyBop / dimethylformamide / 4 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen bromide; acetic acid; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm050377l

Reference yield:

{2-[1-(benzyloxycarbonylamino-methyl)-3-chloro-2-oxo-propylcarbamoyl]-2-tert-butoxycarbonylamino-ethyl}-carbamic acid benzyl ester (693222-13-8) → C59H72N8O11 (872043-66-8)

Guidance literature:

Multi-step reaction with 4 steps

1: HCl / dioxane

2: methanol / 1 h / Heating

3: HBr; AcOH / 3 h / 20 °C

4: 144 mg / DIPEA; PyBop / dimethylformamide / 4 h / 20 °C

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen bromide; acetic acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm050377l

upstream raw materials:

3,6-bis(aminomethyl)-5-methyl-1,2-dihydropyrazin-2-one

3,6-bis(benzyloxycarbonylaminomethyl)-5-methyl-1,2-dihydropyrazin-2-one

{2-[1-(benzyloxycarbonylamino-methyl)-3-chloro-2-oxo-propylcarbamoyl]-2-tert-butoxycarbonylamino-ethyl}-carbamic acid benzyl ester