(-)-(2'R,3'S,4'R,6'R)-6'-(2-(tert-butyldiphenylsilyloxy)ethyl)-4'-(triisopropylsilyloxy)-3',4,4',5,5',6'-hexahydro-1H-spiro[benzo[c]oxepine-3,2'-pyran]-3'-ol

Base Information Edit

Chemical Name:(-)-(2'R,3'S,4'R,6'R)-6'-(2-(tert-butyldiphenylsilyloxy)ethyl)-4'-(triisopropylsilyloxy)-3',4,4',5,5',6'-hexahydro-1H-spiro[benzo[c]oxepine-3,2'-pyran]-3'-ol
CAS No.:1177259-16-3
Molecular Formula:C₄₁H₆₀O₅Si₂
Molecular Weight:689.095
Hs Code.:
Mol file:1177259-16-3.mol

Synonyms:(-)-(2'R,3'S,4'R,6'R)-6'-(2-(tert-butyldiphenylsilyloxy)ethyl)-4'-(triisopropylsilyloxy)-3',4,4',5,5',6'-hexahydro-1H-spiro[benzo[c]oxepine-3,2'-pyran]-3'-ol

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Chemical Property of (-)-(2'R,3'S,4'R,6'R)-6'-(2-(tert-butyldiphenylsilyloxy)ethyl)-4'-(triisopropylsilyloxy)-3',4,4',5,5',6'-hexahydro-1H-spiro[benzo[c]oxepine-3,2'-pyran]-3'-ol Edit

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Technology Process of (-)-(2'R,3'S,4'R,6'R)-6'-(2-(tert-butyldiphenylsilyloxy)ethyl)-4'-(triisopropylsilyloxy)-3',4,4',5,5',6'-hexahydro-1H-spiro[benzo[c]oxepine-3,2'-pyran]-3'-ol

There total 18 articles about (-)-(2'R,3'S,4'R,6'R)-6'-(2-(tert-butyldiphenylsilyloxy)ethyl)-4'-(triisopropylsilyloxy)-3',4,4',5,5',6'-hexahydro-1H-spiro[benzo[c]oxepine-3,2'-pyran]-3'-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1177258-99-9
(+)-(2-(2-((2R,4R)-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)ethyl)phenyl)methanol

: 1177259-16-3
(-)-(2'R,3'S,4'R,6'R)-6'-(2-(tert-butyldiphenylsilyloxy)ethyl)-4'-(triisopropylsilyloxy)-3',4,4',5,5',6'-hexahydro-1H-spiro[benzo[c]oxepine-3,2'-pyran]-3'-ol

Guidance literature:: (+)-(2-(2-((2R,4R)-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)ethyl)phenyl)methanol; With 3,3-dimethyldioxirane; In dichloromethane; acetone; at -78 ℃; for 0.166667h; Inert atmosphere;

With titanium(IV) isopropylate; In dichloromethane; acetone; at -78 - 0 ℃; optical yield given as %de; stereoselective reaction; Inert atmosphere;
DOI:10.1021/ol901437f

Reference yield: 43.0%

: 1177258-99-9
(+)-(2-(2-((2R,4R)-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)ethyl)phenyl)methanol

: 1177259-31-2
(+)-(2'S,3'S,4'R,6'R)-6'-(2-(tert-butyldiphenylsilyloxy)ethyl)-4'-(triisopropylsilyloxy)-3',4,4',5,5',6'-hexahydro-1H-spiro[benzo[c]oxepine-3,2'-pyran]-3'-ol

: 1177259-16-3
(-)-(2'R,3'S,4'R,6'R)-6'-(2-(tert-butyldiphenylsilyloxy)ethyl)-4'-(triisopropylsilyloxy)-3',4,4',5,5',6'-hexahydro-1H-spiro[benzo[c]oxepine-3,2'-pyran]-3'-ol

Guidance literature:: With 3,3-dimethyldioxirane; acetic acid; In dichloromethane; acetone; at -63 - -44 ℃; stereoselective reaction;
DOI:10.1021/ol901437f