1-(p-toluenesulfonyl)-3-trimethylsilyl-4-(trans-2-methoxycarbonyl-ethenyl)-1H-pyrrole

Base Information

Chemical Name:1-(p-toluenesulfonyl)-3-trimethylsilyl-4-(trans-2-methoxycarbonyl-ethenyl)-1H-pyrrole
CAS No.:278167-51-4
Molecular Formula:C₁₈H₂₃NO₄SSi
Molecular Weight:377.536
Hs Code.:

Synonyms:1-(p-toluenesulfonyl)-3-trimethylsilyl-4-(trans-2-methoxycarbonyl-ethenyl)-1H-pyrrole

Suppliers and Price of 1-(p-toluenesulfonyl)-3-trimethylsilyl-4-(trans-2-methoxycarbonyl-ethenyl)-1H-pyrrole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(p-toluenesulfonyl)-3-trimethylsilyl-4-(trans-2-methoxycarbonyl-ethenyl)-1H-pyrrole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(p-toluenesulfonyl)-3-trimethylsilyl-4-(trans-2-methoxycarbonyl-ethenyl)-1H-pyrrole

There total 1 articles about 1-(p-toluenesulfonyl)-3-trimethylsilyl-4-(trans-2-methoxycarbonyl-ethenyl)-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 221656-20-8
1-(p-toluenesulfonyl)-3,4-bis(trimethylsilyl)-1H-pyrrole

: 278167-51-4
1-(p-toluenesulfonyl)-3-trimethylsilyl-4-(trans-2-methoxycarbonyl-ethenyl)-1H-pyrrole

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / silver trifluoroacetate; I₂ / tetrahydrofuran / 1 h / -45 °C

2: 94 percent / Et₃N / PdCl₂(PPh₃)2 / dimethylformamide / 1 h / 100 - 120 °C

With iodine; silver trifluoroacetate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Substitution / 2: Heck coupling reaction;
DOI:10.1021/jo991531c

Reference yield: 62.0%

: 278167-51-4
1-(p-toluenesulfonyl)-3-trimethylsilyl-4-(trans-2-methoxycarbonyl-ethenyl)-1H-pyrrole

: 278167-58-1
1-(p-toluenesulfonyl)-3-iodo-4-(trans-2-methoxycarbonylethenyl)-1H-pyrrole

Guidance literature:: With iodine; silver trifluoroacetate; In tetrahydrofuran; at 20 ℃; for 0.333333h;
DOI:10.1021/jo991531c

Reference yield:

: 278167-51-4
1-(p-toluenesulfonyl)-3-trimethylsilyl-4-(trans-2-methoxycarbonyl-ethenyl)-1H-pyrrole

: 3-phenyl-4-(trans-2-methoxycarbonylethenyl)-1H-pyrrole

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / silver trifluoroacetate; I₂ / tetrahydrofuran / 0.33 h / 20 °C

2: 66 percent / Na₂CO₃ / Pd(PPh₃)4 / methanol; toluene / 3 h / 110 °C

3: 96 percent / TBAF / tetrahydrofuran / 3 h / 60 °C

With tetrabutyl ammonium fluoride; iodine; silver trifluoroacetate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; toluene; 1: Substitution / 2: Suzuki coupling reaction / 3: Substitution;
DOI:10.1021/jo991531c