<2S-(1E,2α,3β,5α)>-<2,3-bis(acetyloxy)-2-methyl-5-(1-methylethenyl)cyclohexylidene>acetic acid ethyl ester

Base Information

• Chemical Name: <2S-(1E,2α,3β,5α)>-<2,3-bis(acetyloxy)-2-methyl-5-(1-methylethenyl)cyclohexylidene>acetic acid ethyl ester
• CAS No.: 81506-18-5
• Molecular Formula: C₁₈H₂₆O₆
• Molecular Weight: 338.401
• Mol file: 81506-18-5.mol

Synonyms:<2S-(1E,2α,3β,5α)>-<2,3-bis(acetyloxy)-2-methyl-5-(1-methylethenyl)cyclohexylidene>acetic acid ethyl ester

Chemical Property of <2S-(1E,2α,3β,5α)>-<2,3-bis(acetyloxy)-2-methyl-5-(1-methylethenyl)cyclohexylidene>acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of <2S-(1E,2α,3β,5α)>-<2,3-bis(acetyloxy)-2-methyl-5-(1-methylethenyl)cyclohexylidene>acetic acid ethyl ester

There total 2 articles about <2S-(1E,2α,3β,5α)>-<2,3-bis(acetyloxy)-2-methyl-5-(1-methylethenyl)cyclohexylidene>acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

<2S-(1E,2α,3β,5α)>-<2-(acetyloxy)-3-hydroxy-2-methyl-5-(1-methylethenyl)cyclohexylidene>acetic acid ethyl ester (81506-17-4) + acetic anhydride (108-24-7) → <2S-(1E,2α,3β,5α)>-<2,3-bis(acetyloxy)-2-methyl-5-(1-methylethenyl)cyclohexylidene>acetic acid ethyl ester (81506-18-5)

Guidance literature:

In pyridine; at 25 ℃;

DOI:10.1021/ja00374a052

Reference yield: 92.0%

<2S-(1E,2α,3β,5α)>-<2-(acetyloxy)-3-hydroxy-2-methyl-5-(1-methylethenyl)cyclohexylidene>acetic acid ethyl ester (81506-17-4) → <2S-(1E,2α,3β,5α)>-<2,3-bis(acetyloxy)-2-methyl-5-(1-methylethenyl)cyclohexylidene>acetic acid ethyl ester (81506-18-5)

Guidance literature:

With pyridine; acetic anhydride; for 15h; Ambient temperature;

DOI:10.1021/jo00366a004

Reference yield: 97.0%

<2S-(1E,2α,3β,5α)>-<2,3-bis(acetyloxy)-2-methyl-5-(1-methylethenyl)cyclohexylidene>acetic acid ethyl ester (81506-18-5) → <2S-(1E,2α,3β,5α)>-<5-acetyl-2,3-bis(acetyloxy)-2-methyl-cyclohexylidene>acetic acid ethyl ester (81506-19-6)

Guidance literature:

With osmium(VIII) oxide; potassium metaperiodate; In tetrahydrofuran; water; for 16h; Ambient temperature;

DOI:10.1021/jo00366a004

upstream raw materials:

<2S-(1E,2α,3β,5α)>-<2-(acetyloxy)-3-hydroxy-2-methyl-5-(1-methylethenyl)cyclohexylidene>acetic acid ethyl ester

acetic anhydride

Downstream raw materials:

<2S-(1E,2α,3β,5α)>-<5-acetyl-2,3-bis(acetyloxy)-2-methyl-cyclohexylidene>acetic acid ethyl ester

calcitriol

<3S-(1Z,3α,5β)>-<3,5-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-methylenecyclohexylidene>acetic acid ethyl ester

[3S-(1Z,3α,5β)]-2-[3,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethanol