N_α-carbobenzyloxy-2,3-diamino-L-propionylglycin tert-butyl ester

Base Information

• Chemical Name: N_α-carbobenzyloxy-2,3-diamino-L-propionylglycin tert-butyl ester
• CAS No.: 403736-54-9
• Molecular Formula: C₁₇H₂₅N₃O₅
• Molecular Weight: 351.403
• Mol file: 403736-54-9.mol

Synonyms:N_α-carbobenzyloxy-2,3-diamino-L-propionylglycin tert-butyl ester

Chemical Property of N_α-carbobenzyloxy-2,3-diamino-L-propionylglycin tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N_α-carbobenzyloxy-2,3-diamino-L-propionylglycin tert-butyl ester

There total 3 articles about N_α-carbobenzyloxy-2,3-diamino-L-propionylglycin tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

[2-benzyloxycarbonylamino-3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-acetic acid tert-butyl ester (403736-50-5) → Nα-carbobenzyloxy-2,3-diamino-L-propionylglycin tert-butyl ester (403736-54-9)

Guidance literature:

With diethylamine; In acetonitrile; at 20 ℃; for 12h;

DOI:10.1016/S0968-0896(01)00228-0

Reference yield:

glycine tert-butyl ester hydrochloride (27532-96-3) → Nα-carbobenzyloxy-2,3-diamino-L-propionylglycin tert-butyl ester (403736-54-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / EDC hydrochloride; triethylamine / CH₂Cl₂ / 12 h / 20 °C

2: 93 percent / diethylamine / acetonitrile / 12 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1016/S0968-0896(01)00228-0

Reference yield:

Nα-Cbz-Nβ-Fmoc-Apa (142855-80-9) → Nα-carbobenzyloxy-2,3-diamino-L-propionylglycin tert-butyl ester (403736-54-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / EDC hydrochloride; triethylamine / CH₂Cl₂ / 12 h / 20 °C

2: 93 percent / diethylamine / acetonitrile / 12 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1016/S0968-0896(01)00228-0

upstream raw materials:

[2-benzyloxycarbonylamino-3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-acetic acid tert-butyl ester

glycine tert-butyl ester hydrochloride

N^α-Cbz-N^β-Fmoc-Apa

Downstream raw materials:

[2-benzyloxycarbonylamino-3-(3-methoxy-[1,2,4]thiadiazol-5-ylamino)-propionylamino]-acetic acid tert-butyl ester