methyl (trans-4-{4-[{[4,6-dichloro-2-(methylsulfanyl)pyrimidin-5-yl]carbonyl}(2-hydroxyethyl)amino]phenyl}cyclohexyl)acetate

Base Information

Chemical Name:methyl (trans-4-{4-[{[4,6-dichloro-2-(methylsulfanyl)pyrimidin-5-yl]carbonyl}(2-hydroxyethyl)amino]phenyl}cyclohexyl)acetate
CAS No.:1394002-57-3
Molecular Formula:C₂₃H₂₇Cl₂N₃O₄S
Molecular Weight:512.457
Hs Code.:

Synonyms:methyl (trans-4-{4-[{[4,6-dichloro-2-(methylsulfanyl)pyrimidin-5-yl]carbonyl}(2-hydroxyethyl)amino]phenyl}cyclohexyl)acetate

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Chemical Property of methyl (trans-4-{4-[{[4,6-dichloro-2-(methylsulfanyl)pyrimidin-5-yl]carbonyl}(2-hydroxyethyl)amino]phenyl}cyclohexyl)acetate

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Technology Process of methyl (trans-4-{4-[{[4,6-dichloro-2-(methylsulfanyl)pyrimidin-5-yl]carbonyl}(2-hydroxyethyl)amino]phenyl}cyclohexyl)acetate

There total 6 articles about methyl (trans-4-{4-[{[4,6-dichloro-2-(methylsulfanyl)pyrimidin-5-yl]carbonyl}(2-hydroxyethyl)amino]phenyl}cyclohexyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1394002-56-2
methyl (trans-4-{4-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl){[4,6-dichloro-2-(methylsulfanyl)-pyrimidin-5-yl]carbonyl}amino]phenyl}cyclohexyl)acetate

: 1394002-57-3
methyl (trans-4-{4-[{[4,6-dichloro-2-(methylsulfanyl)pyrimidin-5-yl]carbonyl}(2-hydroxyethyl)amino]phenyl}cyclohexyl)acetate

Guidance literature:: methyl (trans-4-{4-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl){[4,6-dichloro-2-(methylsulfanyl)-pyrimidin-5-yl]carbonyl}amino]phenyl}cyclohexyl)acetate; With hydrogenchloride; water; In methanol; at 20 ℃; for 1h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 701232-66-8
[4-(4-hydroxyphenyl)cyclohexylidene]acetic acid methyl ester

: 1394002-57-3
methyl (trans-4-{4-[{[4,6-dichloro-2-(methylsulfanyl)pyrimidin-5-yl]carbonyl}(2-hydroxyethyl)amino]phenyl}cyclohexyl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium on activated charcoal / ethyl acetate / 20 °C

2.1: triethylamine / chloroform / 1 h / 0 °C / Inert atmosphere

3.1: caesium carbonate / palladium diacetate; XPhos / toluene / 116 °C / Inert atmosphere; Sealed tube

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Inert atmosphere

4.2: 1 h / 0 - 20 °C

5.1: hydrogenchloride; water / methanol / 1 h / 20 °C

With hydrogenchloride; oxalyl dichloride; water; hydrogen; caesium carbonate; triethylamine; palladium on activated charcoal; palladium diacetate; N,N-dimethyl-formamide; XPhos; In methanol; dichloromethane; chloroform; ethyl acetate; toluene;

Reference yield:

: 105640-07-1
4-(4-hydroxyphenyl)cyclohexan-1-one

: 1394002-57-3
methyl (trans-4-{4-[{[4,6-dichloro-2-(methylsulfanyl)pyrimidin-5-yl]carbonyl}(2-hydroxyethyl)amino]phenyl}cyclohexyl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 0 - 20 °C / Inert atmosphere

1.2: 2 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogen / palladium on activated charcoal / ethyl acetate / 20 °C

3.1: triethylamine / chloroform / 1 h / 0 °C / Inert atmosphere

4.1: caesium carbonate / palladium diacetate; XPhos / toluene / 116 °C / Inert atmosphere; Sealed tube

5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Inert atmosphere

5.2: 1 h / 0 - 20 °C

6.1: hydrogenchloride; water / methanol / 1 h / 20 °C

With hydrogenchloride; oxalyl dichloride; water; hydrogen; sodium hydride; caesium carbonate; triethylamine; palladium on activated charcoal; palladium diacetate; N,N-dimethyl-formamide; XPhos; In tetrahydrofuran; methanol; dichloromethane; chloroform; ethyl acetate; toluene; mineral oil;