N-(2-fluorobenzyl)-4-({(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl}methyl)-N-methyl-N-methylbenzamide trifluoroacetate

Base Information

Chemical Name:N-(2-fluorobenzyl)-4-({(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl}methyl)-N-methyl-N-methylbenzamide trifluoroacetate
CAS No.:1269615-20-4
Molecular Formula:C₂HF₃O₂*C₂₇H₂₉FN₂O₂
Molecular Weight:546.562
Hs Code.:

Synonyms:N-(2-fluorobenzyl)-4-({(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl}methyl)-N-methyl-N-methylbenzamide trifluoroacetate

Suppliers and Price of N-(2-fluorobenzyl)-4-({(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl}methyl)-N-methyl-N-methylbenzamide trifluoroacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(2-fluorobenzyl)-4-({(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl}methyl)-N-methyl-N-methylbenzamide trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(2-fluorobenzyl)-4-({(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl}methyl)-N-methyl-N-methylbenzamide trifluoroacetate

There total 21 articles about N-(2-fluorobenzyl)-4-({(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl}methyl)-N-methyl-N-methylbenzamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1269615-55-5
tert-butyl (2R,5S)-2-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]-5-{4-[(2-fluorobenzyl)(methyl)carbamoyl]benzyl}pyrrolidine-1-carboxylate

: 76-05-1
trifluoroacetic acid

: 1269615-20-4
N-(2-fluorobenzyl)-4-({(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl}methyl)-N-methyl-N-methylbenzamide trifluoroacetate

Guidance literature:: With water; In acetonitrile; at 20 ℃;

Reference yield:

: 589-87-7
1,4-bromoiodobenzene

: 1269615-20-4
N-(2-fluorobenzyl)-4-({(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl}methyl)-N-methyl-N-methylbenzamide trifluoroacetate

Guidance literature:: Multi-step reaction with 10 steps

1.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; copper(l) iodide / N,N-dimethyl-formamide / 6 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3.1: platinum(II) chloride / toluene / 6 h / 80 °C / Inert atmosphere

4.1: sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

6.1: triethylamine / palladium diacetate / 120 °C

7.1: water; lithium hydroxide / methanol / 20 °C

7.2: pH 4.5

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 20 °C

9.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C

10.1: water / acetonitrile / 20 °C

With water; sodium tris(acetoxy)borohydride; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; platinum(II) chloride; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;

Reference yield:

: tert-butyl (4S,5R)-4-formyl-2,2-dimethyl-5-phenyloxazolidine-3-carboxylate

: 1269615-20-4
N-(2-fluorobenzyl)-4-({(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl}methyl)-N-methyl-N-methylbenzamide trifluoroacetate

Guidance literature:: Multi-step reaction with 14 steps

1.1: dichloromethane / 40 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / acetone / 24 h / 20 °C

3.1: sodium t-butanolate / dimethyl sulfoxide / 0.75 h / 20 °C

3.2: 1.5 h / 20 °C

4.1: acetyl chloride; methanol / 5 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 2 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4.5 h / -78 - 20 °C

7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

8.1: triphenylphosphine / palladium diacetate / ethanol / Inert atmosphere; Reflux

9.1: hydrogen / palladium 10% on activated carbon / ethanol / 50 °C

10.1: tetrahydrofuran / 20 °C

11.1: water; lithium hydroxide / methanol / 20 °C

11.2: pH 4.5

12.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 20 °C

13.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C

14.1: water / acetonitrile / 20 °C

With methanol; water; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; acetyl chloride; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; HATU; lithium hydroxide; sodium t-butanolate; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; acetonitrile; mineral oil;