2-Propylpiperidine hydrochloride

Base Information

• Chemical Name: 2-Propylpiperidine hydrochloride
• CAS No.: 15991-59-0
• Molecular Formula: C₈H₁₇N*ClH
• Molecular Weight: 163.691
• Hs Code.: 2933399090
• European Community (EC) Number: 818-918-2
• DSSTox Substance ID: DTXSID60936194
• Mol file: 15991-59-0.mol

Synonyms:2-propylpiperidine hydrochloride;15991-59-0;2-propylpiperidine HCl;51541-42-5;(+)-Coniine hydrochloride;2-propylpiperidine;hydrochloride;(+/-)-2-PROPYLPIPERIDINE HYDROCHLORIDE*;CONIINE, HYDROCHLORIDE;2-Propylpiperidinehydrochloride;Coniin hydrochloride;(S)-Coniine hydrochloride;( inverted exclamation markA)-Coniine (hydrochloride);(S)-(+)-Coniine hydrochloride;EINECS 209-111-0;NSC 15128;Piperidine, 2-propyl-, hydrochloride, (S)-;C8H17N.ClH;Prestwick_126;Piperidine, 2-propyl-, hydrochloride (1:1);C8H17N.HCl;SCHEMBL25356;Coniine hydrochloride (D,L);2-propyl-piperidine hydrochloride;DTXSID60936194;JXBWZNQZRWZJIR-UHFFFAOYSA-N;coniine hydrochloride, (S)-isomer;MFCD00050919;AKOS000277464;AKOS016845961;HY-W099757;SB43089;SB44547;AS-65456;LS-54770;A7600;CS-0152399;2-Propylpiperidine--hydrogen chloride (1/1);EN300-135239;Y10685;Z1665033554

Chemical Property of 2-Propylpiperidine hydrochloride

Chemical Property:

• Vapor Pressure: 1.8mmHg at 25°C
• Melting Point: ~210 °C(lit.)
• Boiling Point: 166.2°C at 760 mmHg
• Flash Point: 48.4°C
• PSA: 12.03000
• LogP: 3.05940
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 163.1127773
• Heavy Atom Count: 10
• Complexity: 71

Purity/Quality:

98% ^*data from raw suppliers

2-Propylpiperidine hydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCC1CCCCN1.Cl

Technology Process of 2-Propylpiperidine hydrochloride

There total 119 articles about 2-Propylpiperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2R,2'S)-(+)-2-phenyl-2-(2'-propyl-piperidin-1'-yl)-ethanol (88056-96-6) → (S)-coniine hydrochloride (555-92-0,15991-59-0,51541-42-5,88057-03-8)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1016/j.tetasy.2004.01.017

Reference yield: 100.0%

benzyl (S)-2-propylpiperidine-1-carboxylate (934016-33-8) → (S)-coniine hydrochloride (555-92-0,15991-59-0,51541-42-5,88057-03-8)

Guidance literature:

With hydrogenchloride; In methanol;

Reference yield: 100.0%

(2S)-2-propyl-1-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)piperidine (121675-94-3) → (S)-coniine hydrochloride (555-92-0,15991-59-0,51541-42-5,88057-03-8)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 36h;

DOI:10.1002/ejoc.200400169

upstream raw materials:

benzyl (S)-2-propylpiperidine-1-carboxylate

N-(benzyloxycarbonyl)-(6S)-4-(1,3-dithiolan-4-yl)-6-n-propylpiperidine

(2R)-(-)-1-((1S)-1-phenylethyl)-2-(1-prop-2-enyl)piperidine

(2S)-2-propyl-1-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)piperidine

Refernces

• 1、 Li, Wei-Sian,Kuo, Ting-Shen,Hsieh, Meng-Chi,Tsai, Ming-Kang,Wu, Ping-Yu,Wu, Hsyueh-Liang. "Enantioselective Rhodium-Catalyzed Allylation of Aliphatic Imines: Synthesis of Chiral C Aliphatic Homoallylic Amines". supporting information. p. 5675 - 5679. Retrieved 2020/08/10.
• 2、 Barange, Deepak Kumar,Johnson, Magnus T.,Cairns, Andrew G.,Olsson, Roger,Almqvist, Fredrik. "Regio- and Stereoselective Alkylation of Pyridine-N-oxides: Synthesis of Substituted Piperidines and Pyridines". supporting information. p. 6228 - 6231. Retrieved 2016/12/23.