6-{[2-(1,3-benzothiazol-2-ylamino)-2-oxoethyl]thio}-5-cyano-N-(2,6-dimethylphenyl)-4-(2-furyl)-2-methyl-1,4-dihydropyridine-3-carboxamide

Base Information

• Chemical Name: 6-{[2-(1,3-benzothiazol-2-ylamino)-2-oxoethyl]thio}-5-cyano-N-(2,6-dimethylphenyl)-4-(2-furyl)-2-methyl-1,4-dihydropyridine-3-carboxamide
• CAS No.: 897833-81-7
• Molecular Formula: C₂₉H₂₅N₅O₃S₂
• Molecular Weight: 555.681
• Mol file: 897833-81-7.mol

Synonyms:6-{[2-(1,3-benzothiazol-2-ylamino)-2-oxoethyl]thio}-5-cyano-N-(2,6-dimethylphenyl)-4-(2-furyl)-2-methyl-1,4-dihydropyridine-3-carboxamide

Chemical Property of 6-{[2-(1,3-benzothiazol-2-ylamino)-2-oxoethyl]thio}-5-cyano-N-(2,6-dimethylphenyl)-4-(2-furyl)-2-methyl-1,4-dihydropyridine-3-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-{[2-(1,3-benzothiazol-2-ylamino)-2-oxoethyl]thio}-5-cyano-N-(2,6-dimethylphenyl)-4-(2-furyl)-2-methyl-1,4-dihydropyridine-3-carboxamide

There total 5 articles about 6-{[2-(1,3-benzothiazol-2-ylamino)-2-oxoethyl]thio}-5-cyano-N-(2,6-dimethylphenyl)-4-(2-furyl)-2-methyl-1,4-dihydropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

C20H19N3O2S*C5H11NO (1448815-94-8) + N-benzothiazol-2-yl-2-chloroacetamide (3028-02-2) → 6-{[2-(1,3-benzothiazol-2-ylamino)-2-oxoethyl]thio}-5-cyano-N-(2,6-dimethylphenyl)-4-(2-furyl)-2-methyl-1,4-dihydropyridine-3-carboxamide (897833-81-7)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 40 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1021/ml400226s

Reference yield:

furfural (98-01-1) → 6-{[2-(1,3-benzothiazol-2-ylamino)-2-oxoethyl]thio}-5-cyano-N-(2,6-dimethylphenyl)-4-(2-furyl)-2-methyl-1,4-dihydropyridine-3-carboxamide (897833-81-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 4-methyl-morpholine / ethanol / 1 h / 20 °C / Inert atmosphere

2: ethanol / 2 h / 20 °C / Inert atmosphere

3: potassium hydroxide / ethanol; water / 40 °C / Inert atmosphere

With 4-methyl-morpholine; potassium hydroxide; In ethanol; water;

DOI:10.1021/ml400226s

Reference yield:

N-(2,6-dimethylphenyl)-3-oxobutanamide (52793-02-9) → 6-{[2-(1,3-benzothiazol-2-ylamino)-2-oxoethyl]thio}-5-cyano-N-(2,6-dimethylphenyl)-4-(2-furyl)-2-methyl-1,4-dihydropyridine-3-carboxamide (897833-81-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 2 h / 20 °C / Inert atmosphere

2: potassium hydroxide / ethanol; water / 40 °C / Inert atmosphere

With potassium hydroxide; In ethanol; water;

DOI:10.1021/ml400226s

upstream raw materials:

N-(2,6-dimethylphenyl)-3-oxobutanamide

C₂₀H₁₉N₃O₂S*C₅H₁₁NO

N-benzothiazol-2-yl-2-chloroacetamide

furfural