N-(2-(benzyloxy)-5-methylphenyl)-N-(3-(4-methoxytetrahydro-2H-pyran-4-yl)benzyl)methanesulfonamide

Base Information

Chemical Name:N-(2-(benzyloxy)-5-methylphenyl)-N-(3-(4-methoxytetrahydro-2H-pyran-4-yl)benzyl)methanesulfonamide
CAS No.:1289485-98-8
Molecular Formula:C₂₈H₃₃NO₅S
Molecular Weight:495.64
Hs Code.:

Synonyms:N-(2-(benzyloxy)-5-methylphenyl)-N-(3-(4-methoxytetrahydro-2H-pyran-4-yl)benzyl)methanesulfonamide

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Chemical Property of N-(2-(benzyloxy)-5-methylphenyl)-N-(3-(4-methoxytetrahydro-2H-pyran-4-yl)benzyl)methanesulfonamide

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Technology Process of N-(2-(benzyloxy)-5-methylphenyl)-N-(3-(4-methoxytetrahydro-2H-pyran-4-yl)benzyl)methanesulfonamide

There total 9 articles about N-(2-(benzyloxy)-5-methylphenyl)-N-(3-(4-methoxytetrahydro-2H-pyran-4-yl)benzyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1289485-71-7
N-(2-(benzyloxy)-5-methylphenyl)methanesulfonamide

: 144800-91-9
4-(3-(bromomethyl)phenyl)-4-methoxytetrahydro-2H-pyran

: 1289485-98-8
N-(2-(benzyloxy)-5-methylphenyl)-N-(3-(4-methoxytetrahydro-2H-pyran-4-yl)benzyl)methanesulfonamide

Guidance literature:: With potassium carbonate; In acetonitrile; Reflux;
DOI:10.1016/j.bmc.2011.01.043

Reference yield:

: 29943-42-8,143562-54-3
Tetrahydro-4H-pyran-4-one

: 1289485-98-8
N-(2-(benzyloxy)-5-methylphenyl)-N-(3-(4-methoxytetrahydro-2H-pyran-4-yl)benzyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: magnesium / tetrahydrofuran / Reflux

1.2: 1 h / Reflux

2.1: sodium hydride / tetrahydrofuran; mineral oil / 15 h / 20 °C

3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 1.5 h / Reflux

4.1: potassium carbonate / acetonitrile / Reflux

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; potassium carbonate; magnesium; In tetrahydrofuran; tetrachloromethane; acetonitrile; mineral oil;
DOI:10.1016/j.bmc.2011.01.043

Reference yield:

: 1289485-54-6
C₂₂H₁₇NO₃

: 1289485-98-8
N-(2-(benzyloxy)-5-methylphenyl)-N-(3-(4-methoxytetrahydro-2H-pyran-4-yl)benzyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: water; hydrazine / ethanol / 2 h / Reflux

2: pyridine / dichloromethane / 1 h / 20 °C

3: potassium carbonate / acetonitrile / Reflux

With pyridine; water; potassium carbonate; hydrazine; In ethanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmc.2011.01.043