3-ethyl-8-{1-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydropurine-2,6-dione

Base Information

Chemical Name:3-ethyl-8-{1-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydropurine-2,6-dione
CAS No.:1188542-16-6
Molecular Formula:C₂₄H₂₆FN₇O₃
Molecular Weight:479.514
Hs Code.:

Synonyms:3-ethyl-8-{1-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydropurine-2,6-dione

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Chemical Property of 3-ethyl-8-{1-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydropurine-2,6-dione

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Technology Process of 3-ethyl-8-{1-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydropurine-2,6-dione

There total 11 articles about 3-ethyl-8-{1-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydropurine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₄₀FN₇O₄Si

: 1188542-16-6
3-ethyl-8-{1-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydropurine-2,6-dione

Guidance literature:: With hydrogenchloride; In ethanol; water; for 3h; Reflux;
DOI:10.1016/j.ejmech.2016.11.007

Reference yield:

: 857063-08-2
ethyl 1-(4-fluorophenyl)-5-pyrrolidone-3-carboxylate

: 1188542-16-6
3-ethyl-8-{1-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydropurine-2,6-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / ethanol / 3.5 h / 10 - 25 °C

2.1: triethylamine / dichloromethane / 0.25 h / 0 °C

2.2: 1.5 h / 10 - 15 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 75 - 80 °C

4.1: hydrogenchloride / ethanol; water / 3 h / Reflux

With hydrogenchloride; sodium tetrahydroborate; potassium carbonate; triethylamine; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2016.11.007

Reference yield:

: 56617-43-7
1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid

: 1188542-16-6
3-ethyl-8-{1-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydropurine-2,6-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 2 h / 55 - 60 °C

2.1: sodium tetrahydroborate / ethanol / 3.5 h / 10 - 25 °C

3.1: triethylamine / dichloromethane / 0.25 h / 0 °C

3.2: 1.5 h / 10 - 15 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 75 - 80 °C

5.1: hydrogenchloride / ethanol; water / 3 h / Reflux

With hydrogenchloride; sodium tetrahydroborate; thionyl chloride; potassium carbonate; triethylamine; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2016.11.007