2-(O-TOLYL)BENZOTHIAZOLE

Base Information

• Chemical Name: 2-(O-TOLYL)BENZOTHIAZOLE
• CAS No.: 15903-58-9
• Molecular Formula: C14H11 N S
• Molecular Weight: 225.314
• Hs Code.: 2934999090
• Mol file: 15903-58-9.mol

Synonyms:Benzothiazole,2-o-tolyl- (6CI,8CI); 2-(2-Methylphenyl)benzothiazole;2-(2-Tolyl)benzothiazole; 2-o-Tolylbenzothiazole

Chemical Property of 2-(O-TOLYL)BENZOTHIAZOLE

Chemical Property:

• Vapor Pressure: 1.9E-05mmHg at 25°C
• Refractive Index: 1.667
• Boiling Point: 373.6°C at 760 mmHg
• Flash Point: 182.9°C
• PSA: 41.13000
• Density: 1.199g/cm³
• LogP: 4.27170

Purity/Quality:

98%min ^*data from raw suppliers

2-(o-Tolyl)benzothiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(O-TOLYL)BENZOTHIAZOLE

There total 51 articles about 2-(O-TOLYL)BENZOTHIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-methylphenyl aldehyde (529-20-4) + 2-amino-benzenethiol (137-07-5) → 2-(o-Tolyl)benzo[d]thiazole (15903-58-9)

Guidance literature:

With tert.-butylhydroperoxide; iodine; potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 12h; Schlenk technique; Molecular sieve;

DOI:10.1039/c8ob02826e

Reference yield: 99.0%

2-methyl-N-phenylthiobenzamide (22978-26-3) → 2-(o-Tolyl)benzo[d]thiazole (15903-58-9)

Guidance literature:

With dmap; Co^III(dimethylglyoximate)₂(4-NMe₂-C₅H₄N)Cl; [Ni(2,2'-bipyridine)₃][PF₆]₂; sodium glycinate; In acetonitrile; at 20 ℃; for 12h; Inert atmosphere; Irradiation; Schlenk technique;

DOI:10.1021/jacs.5b05665

Reference yield: 97.0%

1,3-Benzothiazole (95-16-9) + ortho-methylphenyl iodide (615-37-2) → 2-(o-Tolyl)benzo[d]thiazole (15903-58-9)

Guidance literature:

With copper(l) iodide; 2-(N-butyl-benzimidazol-2-yl)-6-(diphenylphosphinoxy)phenylchloropalladium(II); caesium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.poly.2017.10.005

upstream raw materials:

2-methylphenyl aldehyde

2-amino-benzenethiol

ortho-methylbenzoic acid

1-chloromethyl-2-methylbenzene

Downstream raw materials:

Cu(C₈H₇O₂)2(C₇H₄NSC₆H₄CH₃)2

di(thiocyanato-N)tetrakis(2-(2'-tolyl)-benzothiazole)nickel(II)

2-(benzo[d]thiazol-2-yl)-3-methylphenyl pivalate

2-(benzo[d]thiazol-2-yl)-3-methylphenyl acetate

Refernces

• 1、 Yang, Zeng-Jie,Gong, Qing-Tian,Yu, Yuan,Lu, Wei-Fan,Wu, Zhe-Ning,Wang, Na,Yu, Xiao-Qi. "Fast and high-efficiency synthesis of 2-substituted benzothiazoles via combining enzyme catalysis and photoredox catalysis in one-pot". supporting information. . Retrieved 2021/01/14.
• 2、 Wang, Hao,Wu, Qi,Zhang, Jian-Dong,Li, Hai-Yan,Li, Hong-Xi. "Photocatalyst- And Transition-Metal-Free Visible-Light-Promoted Intramolecular C(sp2)-S Formation". supporting information. p. 2078 - 2083. Retrieved 2021/04/05.