ethyl 2-[(1S,2R)-2-[(4-methoxybenzyl)oxy]-1-(methoxymethoxy)propyl]acrylate

Base Information

Chemical Name:ethyl 2-[(1S,2R)-2-[(4-methoxybenzyl)oxy]-1-(methoxymethoxy)propyl]acrylate
CAS No.:1374407-44-9
Molecular Formula:C₁₈H₂₆O₆
Molecular Weight:338.401
Hs Code.:

Synonyms:ethyl 2-[(1S,2R)-2-[(4-methoxybenzyl)oxy]-1-(methoxymethoxy)propyl]acrylate

Suppliers and Price of ethyl 2-[(1S,2R)-2-[(4-methoxybenzyl)oxy]-1-(methoxymethoxy)propyl]acrylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 2-[(1S,2R)-2-[(4-methoxybenzyl)oxy]-1-(methoxymethoxy)propyl]acrylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 2-[(1S,2R)-2-[(4-methoxybenzyl)oxy]-1-(methoxymethoxy)propyl]acrylate

There total 2 articles about ethyl 2-[(1S,2R)-2-[(4-methoxybenzyl)oxy]-1-(methoxymethoxy)propyl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1374407-45-0
ethyl 2-{(1S,2R)-1-hydroxy-2-[(4-methoxybenzyl)oxy]propyl}acrylate

: 107-30-2
chloromethyl methyl ether

: 1374407-44-9
ethyl 2-[(1S,2R)-2-[(4-methoxybenzyl)oxy]-1-(methoxymethoxy)propyl]acrylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 24h;
DOI:10.1002/ejoc.201101211

Reference yield:

: 140-88-5,9003-32-1
ethyl acrylate

: 218435-12-2
(2R)-2-[(4-methoxybenzyl)oxy]propanal

: 1374407-44-9
ethyl 2-[(1S,2R)-2-[(4-methoxybenzyl)oxy]-1-(methoxymethoxy)propyl]acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,4-diaza-bicyclo[2.2.2]octane / dimethyl sulfoxide / 24 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 0 - 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide; 1: Baylis-Hillman reaction;
DOI:10.1002/ejoc.201101211

Reference yield:

: 1374407-44-9
ethyl 2-[(1S,2R)-2-[(4-methoxybenzyl)oxy]-1-(methoxymethoxy)propyl]acrylate

: 1374407-53-0
(2R,3R,4R)-4-[(E,3S)-3-{[3-(tert-butyl)diphenylsilyl]oxy}-1-butenyl]-2-methyl-tetrahydro-3,4-furandiol

Guidance literature:: Multi-step reaction with 9 steps

1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 1 h / 0 - 20 °C

2: diisobutylaluminium hydride / dichloromethane / 0.5 h / 0 - 20 °C

3: triethylamine; p-toluenesulfonyl chloride / dichloromethane / 24 h / 0 - 20 °C

4: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

5: triethylamine / dichloromethane / 1 h / 0 - 20 °C

6: ozone / dichloromethane / 1 h / -78 °C

7: tetrahydrofuran / 1 h / -78 °C

8: Hoveyda-Grubbs catalyst second generation / toluene / 1 h / Reflux; Inert atmosphere

9: potassium carbonate / methanol / 0.5 h / 20 °C

With Hoveyda-Grubbs catalyst second generation; diisobutylaluminium hydride; potassium carbonate; ozone; triethylamine; p-toluenesulfonyl chloride; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; methanol; dichloromethane; water; toluene;
DOI:10.1002/ejoc.201101211