3-(4-(2-(5-((tert-butoxycarbonyl(2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenylamino)-3-oxopropanoic acid

Base Information

Chemical Name:3-(4-(2-(5-((tert-butoxycarbonyl(2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenylamino)-3-oxopropanoic acid
CAS No.:1187214-05-6
Molecular Formula:C₃₀H₃₁FN₄O₇S
Molecular Weight:610.663
Hs Code.:

3-(4-(2-(5-((tert-butoxycarbonyl(2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenylamino)-3-oxopropanoic acid

Synonyms:3-(4-(2-(5-((tert-butoxycarbonyl(2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenylamino)-3-oxopropanoic acid

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Chemical Property of 3-(4-(2-(5-((tert-butoxycarbonyl(2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenylamino)-3-oxopropanoic acid

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Technology Process of 3-(4-(2-(5-((tert-butoxycarbonyl(2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenylamino)-3-oxopropanoic acid

There total 6 articles about 3-(4-(2-(5-((tert-butoxycarbonyl(2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenylamino)-3-oxopropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1187214-04-5
methyl 3-(4-(2-(5-((tert-butoxycarbonyl(2-methoxyemyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenylamino)-3-oxopropanoate

: 1187214-05-6
3-(4-(2-(5-((tert-butoxycarbonyl(2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenylamino)-3-oxopropanoic acid

Guidance literature:: methyl 3-(4-(2-(5-((tert-butoxycarbonyl(2-methoxyemyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenylamino)-3-oxopropanoate; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 48h;

With hydrogenchloride; In water; pH=4;

Reference yield:

: 1123837-99-9
N-((6-bromopyridin-3-yl)methyl)-2-methoxyethan-1-amine

: 1187214-05-6
3-(4-(2-(5-((tert-butoxycarbonyl(2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenylamino)-3-oxopropanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 16 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

2.2: 1 h / -78 - 20 °C

2.3: 1 h / Reflux

3.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h

3.2: 0.75 h / 100 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C

5.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 48 h / 20 °C

5.2: pH 4

With n-butyllithium; lithium hydroxide monohydrate; potassium tert-butylate; water; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1123838-02-7
tert-butyl {[6-(7-chlorothieno[3,2-b]pyridin-2-yl)pyridin-3-yl]methyl}(2-methoxyethyl)carbamate

: 1187214-05-6
3-(4-(2-(5-((tert-butoxycarbonyl(2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenylamino)-3-oxopropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h

1.2: 0.75 h / 100 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C

3.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 48 h / 20 °C

3.2: pH 4

With lithium hydroxide monohydrate; potassium tert-butylate; water; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;