tert-butyl [(3-bromo-4-chlorophenyl)(hydroxy)methyl]cyclobutanecarboxylate

Base Information

Chemical Name:tert-butyl [(3-bromo-4-chlorophenyl)(hydroxy)methyl]cyclobutanecarboxylate
CAS No.:1380606-20-1
Molecular Formula:C₁₆H₂₀BrClO₃
Molecular Weight:375.69
Hs Code.:

Synonyms:tert-butyl [(3-bromo-4-chlorophenyl)(hydroxy)methyl]cyclobutanecarboxylate

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Chemical Property of tert-butyl [(3-bromo-4-chlorophenyl)(hydroxy)methyl]cyclobutanecarboxylate

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Technology Process of tert-butyl [(3-bromo-4-chlorophenyl)(hydroxy)methyl]cyclobutanecarboxylate

There total 2 articles about tert-butyl [(3-bromo-4-chlorophenyl)(hydroxy)methyl]cyclobutanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 86265-88-5
3-bromo-4-chloro-benzaldehyde

: 87661-19-6
cyclobutanecarboxylic acid tert-butyl ester

: 1380606-20-1
tert-butyl [(3-bromo-4-chlorophenyl)(hydroxy)methyl]cyclobutanecarboxylate

Guidance literature:: cyclobutanecarboxylic acid tert-butyl ester; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 4h;

3-bromo-4-chloro-benzaldehyde; In tetrahydrofuran; hexane; at 20 ℃;

With ammonium chloride; In tetrahydrofuran; hexane; water;

Reference yield:

: 3721-95-7
Cyclobutanecarboxylic acid

: 1380606-20-1
tert-butyl [(3-bromo-4-chlorophenyl)(hydroxy)methyl]cyclobutanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: boron trifluoride diethyl etherate / tetrahydrofuran / 20 °C / Inert atmosphere

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 4 h / -78 °C

2.2: 20 °C

With n-butyllithium; boron trifluoride diethyl etherate; diisopropylamine; In tetrahydrofuran; hexane;