3-cyclopentyl-2(R)-(3-trifluoromethyl-phenyl)-propionic acid

Base Information

• Chemical Name: 3-cyclopentyl-2(R)-(3-trifluoromethyl-phenyl)-propionic acid
• CAS No.: 1003013-44-2
• Molecular Formula: C₁₅H₁₇F₃O₂
• Molecular Weight: 286.294
• Mol file: 1003013-44-2.mol

Synonyms:3-cyclopentyl-2(R)-(3-trifluoromethyl-phenyl)-propionic acid

Chemical Property of 3-cyclopentyl-2(R)-(3-trifluoromethyl-phenyl)-propionic acid

Chemical Property:

Purity/Quality:

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Technology Process of 3-cyclopentyl-2(R)-(3-trifluoromethyl-phenyl)-propionic acid

There total 1 articles about 3-cyclopentyl-2(R)-(3-trifluoromethyl-phenyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3-cyclopentyl-N-(2(R)-hydroxy-1(R)-methyl-2(R)-phenyl-ethyl)-N-methyl-2(R)-(3-trifluoromethyl-phenyl)-propionamide (1003013-43-1) → 3-cyclopentyl-2(R)-(3-trifluoromethyl-phenyl)-propionic acid (1003013-44-2)

Guidance literature:

With sulfuric acid; water; at 110 ℃; for 16h;

Reference yield:

3-cyclopentyl-2(R)-(3-trifluoromethyl-phenyl)-propionic acid (1003013-44-2) → 3-cyclopentyl-2(R)-(3-trifluoromethyl-phenyl)-propionyl chloride (1003013-52-2)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 25 ℃; for 1h;

Reference yield:

3-cyclopentyl-2(R)-(3-trifluoromethyl-phenyl)-propionic acid (1003013-44-2) → 3-cyclopentyl-N-[1-(2-methoxy-ethyl)-1H-pyrazol-3-yl]-2(R)-(3-trifluoromethyl-phenyl)-propionamide

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 0 - 25 °C

2: 2,6-dimethylpyridine / dichloromethane / 16 h / 0 - 25 °C

With 2,6-dimethylpyridine; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;

upstream raw materials:

3-cyclopentyl-N-(2(R)-hydroxy-1(R)-methyl-2(R)-phenyl-ethyl)-N-methyl-2(R)-(3-trifluoromethyl-phenyl)-propionamide

Downstream raw materials:

3-cyclopentyl-2(R)-(3-trifluoromethyl-phenyl)-propionyl chloride