7-[(1S,2R)-2-(Bis-p-tolylsulfanyl-methyl)-5-oxo-cyclopentyl]-heptanoic acid methyl ester

Base Information

Chemical Name:7-[(1S,2R)-2-(Bis-p-tolylsulfanyl-methyl)-5-oxo-cyclopentyl]-heptanoic acid methyl ester
CAS No.:77970-40-2
Molecular Formula:C₂₈H₃₆O₃S₂
Molecular Weight:484.724
Hs Code.:

Synonyms:7-[(1S,2R)-2-(Bis-p-tolylsulfanyl-methyl)-5-oxo-cyclopentyl]-heptanoic acid methyl ester

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Chemical Property of 7-[(1S,2R)-2-(Bis-p-tolylsulfanyl-methyl)-5-oxo-cyclopentyl]-heptanoic acid methyl ester

Chemical Property:

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Technology Process of 7-[(1S,2R)-2-(Bis-p-tolylsulfanyl-methyl)-5-oxo-cyclopentyl]-heptanoic acid methyl ester

There total 6 articles about 7-[(1S,2R)-2-(Bis-p-tolylsulfanyl-methyl)-5-oxo-cyclopentyl]-heptanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 77852-90-5,78037-79-3,78037-80-6,78037-81-7,78037-82-8
7-{(1S,5R)-2-Oxo-5-[((S)-toluene-4-sulfinyl)-p-tolylsulfanyl-methyl]-cyclopentyl}-heptanoic acid methyl ester

: 77970-40-2
7-[(1S,2R)-2-(Bis-p-tolylsulfanyl-methyl)-5-oxo-cyclopentyl]-heptanoic acid methyl ester

Guidance literature:: With iodine; potassium iodide; Hexamethylphosphorous triamide; In acetonitrile; at 45 ℃; for 5h;
DOI:10.1039/P19810001284

Reference yield:

: 77852-90-5,78037-79-3,78037-80-6,78037-81-7,78037-82-8
7-{(1S,5R)-2-Oxo-5-[(toluene-4-sulfinyl)-p-tolylsulfanyl-methyl]-cyclopentyl}-heptanoic acid methyl ester

: 77970-40-2
7-[(1S,2R)-2-(Bis-p-tolylsulfanyl-methyl)-5-oxo-cyclopentyl]-heptanoic acid methyl ester

Guidance literature:: With iodine; potassium iodide; Hexamethylphosphorous triamide; In acetonitrile; at 45 ℃; for 5h; Yield given;
DOI:10.1039/P19810001284

Reference yield:

: 34546-57-1
2-(6-methoxycarbonylhexyl)cyclopent-2-en-1-one

: 77970-40-2
7-[(1S,2R)-2-(Bis-p-tolylsulfanyl-methyl)-5-oxo-cyclopentyl]-heptanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: n-butyl-lithium, hexamethylphosphoric triamide / tetrahydrofuran; hexane / 1.) -20 deg C, 20 min, 2.) -78 deg C, 30 min

2: 59 percent / iodine, (Me₂N)3P, KI / acetonitrile / 5 h / 45 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; iodine; potassium iodide; Hexamethylphosphorous triamide; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.1039/P19810001284