3-cyclopentyl-2-(4-methanesulfonyl-3-trifluoromethylphenyl)propionic acid methyl ester

Base Information

Chemical Name:3-cyclopentyl-2-(4-methanesulfonyl-3-trifluoromethylphenyl)propionic acid methyl ester
CAS No.:300356-00-7
Molecular Formula:C₁₇H₂₁F₃O₄S
Molecular Weight:378.413
Hs Code.:

Synonyms:3-cyclopentyl-2-(4-methanesulfonyl-3-trifluoromethylphenyl)propionic acid methyl ester

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Chemical Property of 3-cyclopentyl-2-(4-methanesulfonyl-3-trifluoromethylphenyl)propionic acid methyl ester

Chemical Property:

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Technology Process of 3-cyclopentyl-2-(4-methanesulfonyl-3-trifluoromethylphenyl)propionic acid methyl ester

There total 4 articles about 3-cyclopentyl-2-(4-methanesulfonyl-3-trifluoromethylphenyl)propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 300355-99-1
3-cyclopentyl-2-(4-methylsulfanyl-3-trifluoromethylphenyl)propionic acid methyl ester

: 300356-00-7
3-cyclopentyl-2-(4-methanesulfonyl-3-trifluoromethylphenyl)propionic acid methyl ester

Guidance literature:: With m-chloroperoxybenzoic acid; In dichloromethane; water;

Reference yield:

: 220227-47-4
(4-fluoro-3-trifluoromethyl-phenyl)-acetic acid

: 300356-00-7
3-cyclopentyl-2-(4-methanesulfonyl-3-trifluoromethylphenyl)propionic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 52 h / -78 - 25 °C / Inert atmosphere

2.1: sulfuric acid / 24 h / Reflux; Inert atmosphere

3.1: N,N-dimethyl-formamide / 24 h / 100 - 110 °C / Inert atmosphere

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 25 °C / Inert atmosphere

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sulfuric acid; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm3008689

Reference yield:

: 3-cyclopentyl-2-(4-fluoro-3-trifluoromethylphenyl)propionic acid methyl ester

: 300356-00-7
3-cyclopentyl-2-(4-methanesulfonyl-3-trifluoromethylphenyl)propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 24 h / 100 - 110 °C / Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 25 °C / Inert atmosphere

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm3008689