(3S-cis)-3-fluoro-5-<(triphenylmethoxy)methyl>-2-tetrahydrofuranone

Base Information

Chemical Name:(3S-cis)-3-fluoro-5-<(triphenylmethoxy)methyl>-2-tetrahydrofuranone
CAS No.:134455-85-9
Molecular Formula:C₂₄H₂₁FO₃
Molecular Weight:376.427
Hs Code.:

Synonyms:(3S-cis)-3-fluoro-5-<(triphenylmethoxy)methyl>-2-tetrahydrofuranone

Suppliers and Price of (3S-cis)-3-fluoro-5-<(triphenylmethoxy)methyl>-2-tetrahydrofuranone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S-cis)-3-fluoro-5-<(triphenylmethoxy)methyl>-2-tetrahydrofuranone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S-cis)-3-fluoro-5-<(triphenylmethoxy)methyl>-2-tetrahydrofuranone

There total 8 articles about (3S-cis)-3-fluoro-5-<(triphenylmethoxy)methyl>-2-tetrahydrofuranone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 380830-02-4
3-fluoro-5-trityloxymethyl-5H-furan-2-one

: 134455-85-9
(3S-cis)-3-fluoro-5-<(triphenylmethoxy)methyl>-2-tetrahydrofuranone

Guidance literature:: With hydrogen; palladium on activated charcoal; at 20 ℃; for 15h;
DOI:10.1016/j.tetlet.2003.11.020

Reference yield:

: 129940-50-7
(S)-tritylglycidol

: 134455-85-9
(3S-cis)-3-fluoro-5-<(triphenylmethoxy)methyl>-2-tetrahydrofuranone

Guidance literature:: Multi-step reaction with 6 steps

1.1: LDA / tetrahydrofuran / 1 h / 0 °C

1.2: HCl / tetrahydrofuran

2.1: 70 percent / toluene / 2 h / Heating

3.1: 100 percent / urea-hydrogenperoxide; methyltrioxorhenium / CH₂Cl₂ / 3 h / 20 °C

4.1: NaH / tetrahydrofuran / 1.5 h / 0 - 20 °C

4.2: 3.8 g / Selectfluor / dimethylformamide / 3 h / 20 °C

5.1: 100 percent / NaHCO₃ / toluene / 0.17 h / Heating

6.1: 100 percent / hydrogen / Pd/C / 15 h / 20 °C

With hydrogen; urea hydrogen peroxide adduct; methyltrioxorhenium(VII); sodium hydride; sodium hydrogencarbonate; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.tetlet.2003.11.020

Reference yield:

: 380830-01-3
(S)-3-Benzenesulfinyl-5-trityloxymethyl-dihydro-furan-2-one

: 134455-85-9
(3S-cis)-3-fluoro-5-<(triphenylmethoxy)methyl>-2-tetrahydrofuranone

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / tetrahydrofuran / 1.5 h / 0 - 20 °C

1.2: 3.8 g / Selectfluor / dimethylformamide / 3 h / 20 °C

2.1: 100 percent / NaHCO₃ / toluene / 0.17 h / Heating

3.1: 100 percent / hydrogen / Pd/C / 15 h / 20 °C

With hydrogen; sodium hydride; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; toluene;
DOI:10.1016/j.tetlet.2003.11.020