(E)-(S)-2-(4-Methoxy-benzylsulfanyl)-2,4-dimethyl-5-(2-trimethylsilanyl-ethoxymethoxy)-pent-3-enoic acid ethyl ester

Base Information

Chemical Name:(E)-(S)-2-(4-Methoxy-benzylsulfanyl)-2,4-dimethyl-5-(2-trimethylsilanyl-ethoxymethoxy)-pent-3-enoic acid ethyl ester
CAS No.:188443-93-8
Molecular Formula:C₂₃H₃₈O₅SSi
Molecular Weight:454.703
Hs Code.:

Synonyms:(E)-(S)-2-(4-Methoxy-benzylsulfanyl)-2,4-dimethyl-5-(2-trimethylsilanyl-ethoxymethoxy)-pent-3-enoic acid ethyl ester

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Chemical Property of (E)-(S)-2-(4-Methoxy-benzylsulfanyl)-2,4-dimethyl-5-(2-trimethylsilanyl-ethoxymethoxy)-pent-3-enoic acid ethyl ester

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Technology Process of (E)-(S)-2-(4-Methoxy-benzylsulfanyl)-2,4-dimethyl-5-(2-trimethylsilanyl-ethoxymethoxy)-pent-3-enoic acid ethyl ester

There total 9 articles about (E)-(S)-2-(4-Methoxy-benzylsulfanyl)-2,4-dimethyl-5-(2-trimethylsilanyl-ethoxymethoxy)-pent-3-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 188444-23-7
(E)-(S)-5-Hydroxy-2-(4-methoxy-benzylsulfanyl)-2,4-dimethyl-pent-3-enoic acid ethyl ester

: 188443-93-8
(E)-(S)-2-(4-Methoxy-benzylsulfanyl)-2,4-dimethyl-5-(2-trimethylsilanyl-ethoxymethoxy)-pent-3-enoic acid ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 2h;

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 188443-93-8
(E)-(S)-2-(4-Methoxy-benzylsulfanyl)-2,4-dimethyl-5-(2-trimethylsilanyl-ethoxymethoxy)-pent-3-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) KOH / 1.) EtOH, 7 min, 2.) 45 min

2: 1.) O₃, 2.) Me₂S / 1.) MeOH, -78 deg C, 25 min, 2.) -78 deg C to r.t., 3.5 h

3: 79 percent / benzene / 9 h / Heating

4: 89 percent / CF₃CO₂H / CH₂Cl₂ / 1 h

5: oxalyl chloride / benzene / 2 h / 50 °C

6: NaBH(OMe)3 / tetrahydrofuran / 1.5 h / Ambient temperature

7: 89 percent / diisopropylethylamine / CH₂Cl₂ / 2 h

With potassium hydroxide; oxalyl dichloride; dimethylsulfide; sodium trimethoxyborohydride; ozone; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; benzene;

Reference yield:

: 123401-95-6
Ethyl (2S)-2-formyl-2-(4-methoxybenzylthio)propanoate

: 188443-93-8
(E)-(S)-2-(4-Methoxy-benzylsulfanyl)-2,4-dimethyl-5-(2-trimethylsilanyl-ethoxymethoxy)-pent-3-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 79 percent / benzene / 9 h / Heating

2: 89 percent / CF₃CO₂H / CH₂Cl₂ / 1 h

3: oxalyl chloride / benzene / 2 h / 50 °C

4: NaBH(OMe)3 / tetrahydrofuran / 1.5 h / Ambient temperature

5: 89 percent / diisopropylethylamine / CH₂Cl₂ / 2 h

With oxalyl dichloride; sodium trimethoxyborohydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; benzene;