5-tert-butyl-4,5-dichloro-3-(4-chloro-2-fluoro-phenyl)-oxazolidin-2-one

Base Information

• Chemical Name: 5-tert-butyl-4,5-dichloro-3-(4-chloro-2-fluoro-phenyl)-oxazolidin-2-one
• CAS No.: 218939-54-9
• Molecular Formula: C₁₃H₁₃Cl₃FNO₂
• Molecular Weight: 340.609

Synonyms:5-tert-butyl-4,5-dichloro-3-(4-chloro-2-fluoro-phenyl)-oxazolidin-2-one

Chemical Property of 5-tert-butyl-4,5-dichloro-3-(4-chloro-2-fluoro-phenyl)-oxazolidin-2-one

Chemical Property:

Purity/Quality:

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Technology Process of 5-tert-butyl-4,5-dichloro-3-(4-chloro-2-fluoro-phenyl)-oxazolidin-2-one

There total 2 articles about 5-tert-butyl-4,5-dichloro-3-(4-chloro-2-fluoro-phenyl)-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.4%

5-tert-Butyl-3-(4-chloro-2-fluoro-phenyl)-3H-oxazol-2-one (145858-70-4) → 5-tert-butyl-4,5-dichloro-3-(4-chloro-2-fluoro-phenyl)-oxazolidin-2-one (218939-54-9)

Guidance literature:

With chlorine; In tetrachloromethane; Ambient temperature;

DOI:10.1021/jf980281i

Reference yield:

ethyl N-(4-chloro-2-fluorophenyl)carbamate (114108-90-6) → 5-tert-butyl-4,5-dichloro-3-(4-chloro-2-fluoro-phenyl)-oxazolidin-2-one (218939-54-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / LiN(TMS)2 / tetrahydrofuran; dimethylformamide / 0.5 h / Ambient temperature

2: 46.4 percent / Cl₂ / CCl₄ / Ambient temperature

With chlorine; lithium hexamethyldisilazane; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jf980281i

Reference yield: 86.0%

5-tert-butyl-4,5-dichloro-3-(4-chloro-2-fluoro-phenyl)-oxazolidin-2-one (218939-54-9) → 5-tert-butyl-4-chloro-3-(4-chloro-2-fluoro-phenyl)-3H-oxazol-2-one

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethyl sulfoxide; for 2h; Ambient temperature;

DOI:10.1021/jf980281i

upstream raw materials:

5-tert-Butyl-3-(4-chloro-2-fluoro-phenyl)-3H-oxazol-2-one

ethyl N-(4-chloro-2-fluorophenyl)carbamate

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