((2R,6R)-4-methylene-6-(((2R,4S,6R)-4-(triisopropylsilyloxy)-6-(2-(triisopropylsilyloxy)methyl-1,3-oxazol-4-yl)tetrahydro-2H-pyran-2-yl)methyl)tetrahydro-2H-pyran-2-yl)methyl trifluoromethanesulfonate

Base Information

Chemical Name:((2R,6R)-4-methylene-6-(((2R,4S,6R)-4-(triisopropylsilyloxy)-6-(2-(triisopropylsilyloxy)methyl-1,3-oxazol-4-yl)tetrahydro-2H-pyran-2-yl)methyl)tetrahydro-2H-pyran-2-yl)methyl trifluoromethanesulfonate
CAS No.:296795-23-8
Molecular Formula:C₃₆H₆₄F₃NO₈SSi₂
Molecular Weight:784.138
Hs Code.:

((2R,6R)-4-methylene-6-(((2R,4S,6R)-4-(triisopropylsilyloxy)-6-(2-(triisopropylsilyloxy)methyl-1,3-oxazol-4-yl)tetrahydro-2H-pyran-2-yl)methyl)tetrahydro-2H-pyran-2-yl)methyl trifluoromethanesulfonate

Synonyms:((2R,6R)-4-methylene-6-(((2R,4S,6R)-4-(triisopropylsilyloxy)-6-(2-(triisopropylsilyloxy)methyl-1,3-oxazol-4-yl)tetrahydro-2H-pyran-2-yl)methyl)tetrahydro-2H-pyran-2-yl)methyl trifluoromethanesulfonate

Suppliers and Price of ((2R,6R)-4-methylene-6-(((2R,4S,6R)-4-(triisopropylsilyloxy)-6-(2-(triisopropylsilyloxy)methyl-1,3-oxazol-4-yl)tetrahydro-2H-pyran-2-yl)methyl)tetrahydro-2H-pyran-2-yl)methyl trifluoromethanesulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ((2R,6R)-4-methylene-6-(((2R,4S,6R)-4-(triisopropylsilyloxy)-6-(2-(triisopropylsilyloxy)methyl-1,3-oxazol-4-yl)tetrahydro-2H-pyran-2-yl)methyl)tetrahydro-2H-pyran-2-yl)methyl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ((2R,6R)-4-methylene-6-(((2R,4S,6R)-4-(triisopropylsilyloxy)-6-(2-(triisopropylsilyloxy)methyl-1,3-oxazol-4-yl)tetrahydro-2H-pyran-2-yl)methyl)tetrahydro-2H-pyran-2-yl)methyl trifluoromethanesulfonate

There total 1 articles about ((2R,6R)-4-methylene-6-(((2R,4S,6R)-4-(triisopropylsilyloxy)-6-(2-(triisopropylsilyloxy)methyl-1,3-oxazol-4-yl)tetrahydro-2H-pyran-2-yl)methyl)tetrahydro-2H-pyran-2-yl)methyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 296795-23-8
((2R,6R)-4-methylene-6-(((2R,4S,6R)-4-(triisopropylsilyloxy)-6-(2-(triisopropylsilyloxy)methyl-1,3-oxazol-4-yl)tetrahydro-2H-pyran-2-yl)methyl)tetrahydro-2H-pyran-2-yl)methyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 15 steps

1.1: 100 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

2.1: 97 percent / DIBALH / CH₂Cl₂ / 1 h / -94 °C

3.1: triethylamine; di-n-butylboron trifluoromethanesulfonate / CH₂Cl₂ / 1 h / 20 °C

3.2: CH₂Cl₂ / 50 h / -78 - -40 °C

4.1: 91 percent / Zn; AcOH / tetrahydrofuran / 0.25 h / 20 °C

5.1: 100 percent / imidazole; 4-(dimethylamino)pyridine / dimethylformamide / 1 h / 20 °C

6.1: 85 percent / lithium borohydride; H₂O / diethyl ether; tetrahydrofuran / 0.5 h / 20 °C

7.1: 99 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 2.5 h / -78 °C

8.1: diisopropylethylamine; di-n-butylboron trifluoromethanesulfonate / CH₂Cl₂ / 0.5 h / -78 °C

8.2: 82 percent / diethyl ether / 5 h / -105 °C

9.1: 99 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

10.1: pyridinium hydrofluoride; H₂O / tetrahydrofuran; pyridine / 3 h / 0 °C

11.1: 96 percent / triethylsilane; boron trifluoride diethyl etherate / CH₂Cl₂ / 16.5 h / -78 - -50 °C

12.1: 90 percent / FeCl₃*SiO₂ / CHCl₃; acetone / 96 h / 20 °C

13.1: 100 percent / H₂ / Pd/C / propan-2-ol / 48 h / 760.05 Torr

14.1: PhLi / tetrahydrofuran; cyclohexane; diethyl ether / 2 h / 20 °C

14.2: 90 percent / tetrahydrofuran; cyclohexane; diethyl ether / 1 h

15.1: 100 percent / pyridine / CH₂Cl₂ / 0.33 h / -5 °C

With pyridine; 1H-imidazole; 2,6-dimethylpyridine; triethylsilane; dmap; lithium borohydride; oxalyl dichloride; di-n-butylboryl trifluoromethanesulfonate; boron trifluoride diethyl etherate; water; hydrogen; silica gel; iron(III) chloride; diisobutylaluminium hydride; pyridine hydrogenfluoride; acetic acid; dimethyl sulfoxide; phenyllithium; triethylamine; N-ethyl-N,N-diisopropylamine; zinc; palladium on activated charcoal; In tetrahydrofuran; pyridine; diethyl ether; dichloromethane; chloroform; cyclohexane; N,N-dimethyl-formamide; isopropyl alcohol; acetone; 7.1: Swern oxidation / 14.1: Wittig olefination;
DOI:10.1021/ja002356g

Reference yield: 78.0%

: 7341-97-1
N-phenyl propynamide

: 296795-23-8
((2R,6R)-4-methylene-6-(((2R,4S,6R)-4-(triisopropylsilyloxy)-6-(2-(triisopropylsilyloxy)methyl-1,3-oxazol-4-yl)tetrahydro-2H-pyran-2-yl)methyl)tetrahydro-2H-pyran-2-yl)methyl trifluoromethanesulfonate

: 296795-24-9
N-phenyl 4-((2R,6R)-4-methylene-6-(((2R,4S,6R)-4-(triisopropylsilyloxy)-6-(2-(triisopropyloxy)methyl-1,3-oxazol-4-yl)tetrahydro-2H-pyran-2-yl)methyl)tetrahydro-2H-pyran-2-yl)but-2-yn-amide

Guidance literature:: N-phenyl propynamide; With n-butyllithium; In tetrahydrofuran; at -20 ℃;

((2R,6R)-4-methylene-6-(((2R,4S,6R)-4-(triisopropylsilyloxy)-6-(2-(triisopropylsilyloxy)methyl-1,3-oxazol-4-yl)tetrahydro-2H-pyran-2-yl)methyl)tetrahydro-2H-pyran-2-yl)methyl trifluoromethanesulfonate; In tetrahydrofuran;
DOI:10.1002/1521-3773(20000717)39:14<2536::AID-ANIE2536>3.0.CO;2-U

Reference yield:

: 296795-23-8
((2R,6R)-4-methylene-6-(((2R,4S,6R)-4-(triisopropylsilyloxy)-6-(2-(triisopropylsilyloxy)methyl-1,3-oxazol-4-yl)tetrahydro-2H-pyran-2-yl)methyl)tetrahydro-2H-pyran-2-yl)methyl trifluoromethanesulfonate

: 296795-25-0
N-phenyl 4-((2R,6R)-4-methylene-6-(((2R,4S,6R)-4-(triisopropylsilyloxy)-6-(2-(methanesulfonylmethyl)-1,3-oxazol-4-yl)tetrahydro-2H-pyran-2-yl)methyl)tetrahydro-2H-pyran-2-yl)but-2-ynamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 1 h / 0 °C

1.2: 78 percent / tetrahydrofuran; hexane / 18 h / -20 °C

2.1: 99 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1.33 h / -78 - -50 °C

3.1: 99 percent / diisopropylethylamine / CH₂Cl₂ / 0.33 h / -5 °C

With n-butyllithium; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja002356g