1-(4-(3-(Methylcarbamoyl)phenyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

Base Information

Chemical Name:1-(4-(3-(Methylcarbamoyl)phenyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea
CAS No.:620963-03-3
Molecular Formula:C₂₂H₁₇ClF₃N₃O₂
Molecular Weight:447.844
Hs Code.:

Synonyms:1-(4-(3-(Methylcarbamoyl)phenyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

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Chemical Property of 1-(4-(3-(Methylcarbamoyl)phenyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

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Technology Process of 1-(4-(3-(Methylcarbamoyl)phenyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

There total 6 articles about 1-(4-(3-(Methylcarbamoyl)phenyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.2%

: 1335041-46-7
C₁₄H₁₄N₂O

: 327-78-6
4-chloro-3-(trifluoromethyl)phenyl isocyanate

: 620963-03-3
1-(4-(3-(Methylcarbamoyl)phenyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.03.020

Reference yield:

: 3-(4-nitro-phenyl)-benzoyl chloride

: 620963-03-3
1-(4-(3-(Methylcarbamoyl)phenyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 8 h / 0 - 20 °C

2: hydrogen; 5%-palladium/activated carbon / tetrahydrofuran / 6 h

3: dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

With 5%-palladium/activated carbon; hydrogen; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.ejmech.2014.03.020

Reference yield:

: 1598408-84-4
C₁₄H₁₂N₂O₃

: 620963-03-3
1-(4-(3-(Methylcarbamoyl)phenyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; 5%-palladium/activated carbon / tetrahydrofuran / 6 h

2: dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

With 5%-palladium/activated carbon; hydrogen; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.ejmech.2014.03.020