ethyl 2-(methylthio)-4-((pyridin-3-ylmethyl)amino) pyrimidine-5-carboxylate

Base Information

• Chemical Name: ethyl 2-(methylthio)-4-((pyridin-3-ylmethyl)amino) pyrimidine-5-carboxylate
• CAS No.: 1309797-37-2
• Molecular Formula: C₁₄H₁₆N₄O₂S
• Molecular Weight: 304.373
• Mol file: 1309797-37-2.mol

Synonyms:ethyl 2-(methylthio)-4-((pyridin-3-ylmethyl)amino) pyrimidine-5-carboxylate

Chemical Property of ethyl 2-(methylthio)-4-((pyridin-3-ylmethyl)amino) pyrimidine-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(methylthio)-4-((pyridin-3-ylmethyl)amino) pyrimidine-5-carboxylate

There total 1 articles about ethyl 2-(methylthio)-4-((pyridin-3-ylmethyl)amino) pyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-hydroxy-2-(methylthio)pyrimidine-5-carboxylate (53554-29-3) → ethyl 2-(methylthio)-4-((pyridin-3-ylmethyl)amino) pyrimidine-5-carboxylate (1309797-37-2)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 90 °C

2: 1,4-dioxane / 2 h / Reflux

With trichlorophosphate; In 1,4-dioxane;

DOI:10.1002/jccs.201700310

Reference yield:

ethyl 2-(methylthio)-4-((pyridin-3-ylmethyl)amino) pyrimidine-5-carboxylate (1309797-37-2) → 6-(2-chloro-4-(3-methylpyrazin-2-yl)phenyl)-2-(methylthio)-8-(pyridin-3-ylmethyl)pyrido[2,3-d]pyrimidin-7(8H)-one (1432910-01-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -20 - 10 °C / Inert atmosphere

1.2: 0 °C

2.1: manganese(IV) oxide / dichloromethane / Reflux; Inert atmosphere

3.1: potassium carbonate / dichloromethane; N,N-dimethyl-formamide / 70 °C / Inert atmosphere

With manganese(IV) oxide; lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

ethyl 2-(methylthio)-4-((pyridin-3-ylmethyl)amino) pyrimidine-5-carboxylate (1309797-37-2) → tert-butyl 6-(2-chloro-4-(3-methylpyrazin-2-yl)phenyl)-2-(methylsulfinyl)-8-(pyridin-3-ylmethyl)pyrido[2,3-d]pyrimidin-7(8H)-one (1432910-02-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -20 - 10 °C / Inert atmosphere

1.2: 0 °C

2.1: manganese(IV) oxide / dichloromethane / Reflux; Inert atmosphere

3.1: potassium carbonate / dichloromethane; N,N-dimethyl-formamide / 70 °C / Inert atmosphere

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / -10 - 20 °C / Inert atmosphere

With manganese(IV) oxide; lithium aluminium tetrahydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

ethyl 4-hydroxy-2-(methylthio)pyrimidine-5-carboxylate

Downstream raw materials:

6-(2-chloro-4-(3-methylpyrazin-2-yl)phenyl)-2-(methylthio)-8-(pyridin-3-ylmethyl)pyrido[2,3-d]pyrimidin-7(8H)-one

tert-butyl 6-(2-chloro-4-(3-methylpyrazin-2-yl)phenyl)-2-(methylsulfinyl)-8-(pyridin-3-ylmethyl)pyrido[2,3-d]pyrimidin-7(8H)-one

(R)-6-(2-chloro-4-(3-methylpyrazin-2-yl)phenyl)-8-(pyridin-3-ylmethyl)-2-((tetrahydrofuran-3-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one