1-hydroxy-3-methyl-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one

Base Information

Chemical Name:1-hydroxy-3-methyl-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one
CAS No.:1375624-09-1
Molecular Formula:C₂₄H₁₈F₃NO₃
Molecular Weight:425.407
Hs Code.:

Synonyms:1-hydroxy-3-methyl-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one

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Chemical Property of 1-hydroxy-3-methyl-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one

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Technology Process of 1-hydroxy-3-methyl-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one

There total 9 articles about 1-hydroxy-3-methyl-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.4%

: 1379615-72-1
C₂₇H₂₂F₃NO₅

: 1375624-09-1
1-hydroxy-3-methyl-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one

Guidance literature:: C₂₇H₂₂F₃NO₅; With water; potassium hydroxide; In ethanol; at 17 - 25 ℃; for 1h;

With hydrogenchloride; In ethanol; water; at 17 - 25 ℃; pH=1 - 2;

Reference yield:

: 1361004-81-0
CK-2-67

: 1375624-09-1
1-hydroxy-3-methyl-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

1.2: 0.5 h / Inert atmosphere

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere

3.1: potassium hydroxide / ethanol; water / 20 °C / Inert atmosphere

With potassium tert-butylate; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/jm201179h

Reference yield:

: 1361005-40-4
ethyl (3-methyl-2-(4-(4-(trifluoromethoxy)benzyl)phenyl)quinolin-4-yl)carbonate

: 1375624-09-1
1-hydroxy-3-methyl-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere

2: potassium hydroxide / ethanol; water / 20 °C / Inert atmosphere

With 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; In ethanol; dichloromethane; water;
DOI:10.1021/jm201179h