methyl (S)-2-((tert-butoxycarbonyl)(thiazol-5-ylmethyl)amino)-3-phenylpropanoate

Base Information

Chemical Name:methyl (S)-2-((tert-butoxycarbonyl)(thiazol-5-ylmethyl)amino)-3-phenylpropanoate
CAS No.:1442476-78-9
Molecular Formula:C₁₉H₂₄N₂O₄S
Molecular Weight:376.477
Hs Code.:

Synonyms:methyl (S)-2-((tert-butoxycarbonyl)(thiazol-5-ylmethyl)amino)-3-phenylpropanoate

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Chemical Property of methyl (S)-2-((tert-butoxycarbonyl)(thiazol-5-ylmethyl)amino)-3-phenylpropanoate

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Technology Process of methyl (S)-2-((tert-butoxycarbonyl)(thiazol-5-ylmethyl)amino)-3-phenylpropanoate

There total 1 articles about methyl (S)-2-((tert-butoxycarbonyl)(thiazol-5-ylmethyl)amino)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 45438-77-5
5-thiazolylmethyl chloride

: 51987-73-6
(S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester

: 1442476-78-9
methyl (S)-2-((tert-butoxycarbonyl)(thiazol-5-ylmethyl)amino)-3-phenylpropanoate

Guidance literature:: (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester; With sodium hydride; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

5-thiazolylmethyl chloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ml4000854

Reference yield: 81.0%

: 1442476-78-9
methyl (S)-2-((tert-butoxycarbonyl)(thiazol-5-ylmethyl)amino)-3-phenylpropanoate

: 1442476-79-0
(S)-2-((tert-butoxycarbonyl)(thiazol-5-ylmethyl)amino)-3-phenylpropanoic acid

Guidance literature:: With lithium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 0.5h;
DOI:10.1021/ml4000854

Reference yield:

: 1442476-78-9
methyl (S)-2-((tert-butoxycarbonyl)(thiazol-5-ylmethyl)amino)-3-phenylpropanoate

: 1442476-33-6
(S)-3-phenyl-N-(5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl)-2-((thiazol-5-ylmethyl)amino)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hydroxide / water; 1,4-dioxane / 0.5 h / 20 °C

2: trifluoro-[1,3,5]triazine; pyridine / dichloromethane / 1 h / -20 - -10 °C

3: triethylamine / N,N-dimethyl-formamide / 45 °C / Inert atmosphere

4: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C

With pyridine; hydrogenchloride; trifluoro-[1,3,5]triazine; triethylamine; lithium hydroxide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ml4000854