Technology Process of ethyl (2S,3S)-2-bromo-3-hydroxy-3-(4-chlorophenyl)propanoate
There total 6 articles about ethyl (2S,3S)-2-bromo-3-hydroxy-3-(4-chlorophenyl)propanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: K3Fe(CN)6; MeSO2NH2; K2CO3 / OsO4; (DHQ)2-PHAL / 2-methyl-propan-2-ol; H2O; toluene / 24 h / 25 °C
2.1: 86 percent / thionyl chloride; triethylamine / CH2Cl2 / 0.5 h / 0 °C
3.1: NaIO4 / RuCl3 / acetonitrile; H2O / 0.08 h / 0 °C
4.1: LiBr / tetrahydrofuran; acetonitrile; H2O / 1 h / 25 °C
4.2: 1.00 g / H2SO4; H2O / diethyl ether / 5 h / 25 °C
With
sodium periodate; thionyl chloride; methanesulfonamide; potassium carbonate; triethylamine; lithium bromide; potassium hexacyanoferrate(III);
ruthenium trichloride; osmium(VIII) oxide; (DHQ)2-PHAL;
In
tetrahydrofuran; dichloromethane; water; toluene; acetonitrile; tert-butyl alcohol;
1.1: Sharpless asymmetric dihydroxylation;
- Guidance literature:
-
C11H11ClO6S;
With
lithium bromide;
In
tetrahydrofuran; water; acetonitrile;
at 25 ℃;
for 1h;
With
sulfuric acid; water;
In
diethyl ether;
at 25 ℃;
for 5h;
Further stages.;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: NaIO4 / RuCl3 / acetonitrile; H2O / 0.08 h / 0 °C
2.1: LiBr / tetrahydrofuran; acetonitrile; H2O / 1 h / 25 °C
2.2: 1.00 g / H2SO4; H2O / diethyl ether / 5 h / 25 °C
With
sodium periodate; lithium bromide;
ruthenium trichloride;
In
tetrahydrofuran; water; acetonitrile;
