diethyl 2-phthalimido-2-[N-(5-amino-1-benzylimidazolyl-4-carbonyl)amino]malonate

Base Information

• Chemical Name: diethyl 2-phthalimido-2-[N-(5-amino-1-benzylimidazolyl-4-carbonyl)amino]malonate
• CAS No.: 324750-70-1
• Molecular Formula: C₂₆H₂₅N₅O₇
• Molecular Weight: 519.514
• Mol file: 324750-70-1.mol

Synonyms:diethyl 2-phthalimido-2-[N-(5-amino-1-benzylimidazolyl-4-carbonyl)amino]malonate

Chemical Property of diethyl 2-phthalimido-2-[N-(5-amino-1-benzylimidazolyl-4-carbonyl)amino]malonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 2-phthalimido-2-[N-(5-amino-1-benzylimidazolyl-4-carbonyl)amino]malonate

There total 4 articles about diethyl 2-phthalimido-2-[N-(5-amino-1-benzylimidazolyl-4-carbonyl)amino]malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

diethyl 2-phthalimido-2-[N-(1-benzyl-5-nitroimidazolyl-4-carbonyl)amino]malonate (324750-69-8) → diethyl 2-phthalimido-2-[N-(5-amino-1-benzylimidazolyl-4-carbonyl)amino]malonate (324750-70-1)

Guidance literature:

With cyclohexene; palladium on activated charcoal; In ethanol; Heating;

DOI:10.1016/S0040-4039(00)01725-1

Reference yield:

aminomalonic acid diethyl ester (6829-40-9) → diethyl 2-phthalimido-2-[N-(5-amino-1-benzylimidazolyl-4-carbonyl)amino]malonate (324750-70-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 93 percent / 1,1'-carbonyldiimidazole

2.1: NaH; Br₂ / dimethylformamide

2.2: 92 percent / dimethylformamide

3.1: 45 percent / cyclohexene / Pd-C / ethanol / Heating

With bromine; sodium hydride; 1,1'-carbonyldiimidazole; cyclohexene; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)01725-1

Reference yield:

diethyl 2-malonate (155568-39-1) → diethyl 2-phthalimido-2-[N-(5-amino-1-benzylimidazolyl-4-carbonyl)amino]malonate (324750-70-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH; Br₂ / dimethylformamide

1.2: 92 percent / dimethylformamide

2.1: 45 percent / cyclohexene / Pd-C / ethanol / Heating

With bromine; sodium hydride; cyclohexene; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)01725-1

upstream raw materials:

diethyl 2-phthalimido-2-[N-(1-benzyl-5-nitroimidazolyl-4-carbonyl)amino]malonate

aminomalonic acid diethyl ester

diethyl 2-malonate

5-nitro-1-(phenylmethyl)-1H-imidazole-4-carboxylic acid