1-[1-(4-chlorophenyl)-5-cyclobutyl-pyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one

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Chemical Name:1-[1-(4-chlorophenyl)-5-cyclobutyl-pyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one
CAS No.:1613395-33-7
Molecular Formula:C₂₂H₂₁ClF₃N₅O
Molecular Weight:463.89
Hs Code.:

Synonyms:1-[1-(4-chlorophenyl)-5-cyclobutyl-pyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one

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Chemical Property of 1-[1-(4-chlorophenyl)-5-cyclobutyl-pyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one

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Technology Process of 1-[1-(4-chlorophenyl)-5-cyclobutyl-pyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one

There total 9 articles about 1-[1-(4-chlorophenyl)-5-cyclobutyl-pyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: C₂₃H₂₅ClF₃N₅O₄S

: 1613395-33-7
1-[1-(4-chlorophenyl)-5-cyclobutyl-pyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one

Guidance literature:: With triethylamine; In 1,2-dichloro-ethane; at 75 ℃; for 3h;

Reference yield:

: 1613396-57-8
methyl 1-(4-chlorophenyl)-5-cyclobutyl-pyrazole-4-carboxylate

: 1613395-33-7
1-[1-(4-chlorophenyl)-5-cyclobutyl-pyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hydroxide monohydrate; water / methanol; tetrahydrofuran / 1 h / 80 °C

2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 20 °C

3.1: sodium azide / acetone; water / 0 °C

4.1: toluene / 1 h / 95 °C

4.2: 2 h / 20 - 110 °C

5.1: trimethylaluminum / 1,2-dichloro-ethane; toluene / 1.5 h / 20 °C

6.1: triethylamine / dichloromethane / 0.17 h / 0 °C

7.1: triethylamine / 1,2-dichloro-ethane / 3 h / 75 °C

With sodium azide; oxalyl dichloride; lithium hydroxide monohydrate; water; trimethylaluminum; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: C₁₄H₁₂ClN₅O

: 1613395-33-7
1-[1-(4-chlorophenyl)-5-cyclobutyl-pyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 1 h / 95 °C

1.2: 2 h / 20 - 110 °C

2.1: trimethylaluminum / 1,2-dichloro-ethane; toluene / 1.5 h / 20 °C

3.1: triethylamine / dichloromethane / 0.17 h / 0 °C

4.1: triethylamine / 1,2-dichloro-ethane / 3 h / 75 °C

With trimethylaluminum; triethylamine; In dichloromethane; 1,2-dichloro-ethane; toluene;