5-benzyloxy-1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-isoquinoline

Base Information

Chemical Name:5-benzyloxy-1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-isoquinoline
CAS No.:919082-27-2
Molecular Formula:C₂₇H₂₉NO₅
Molecular Weight:447.531
Hs Code.:

Synonyms:5-benzyloxy-1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-isoquinoline

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Chemical Property of 5-benzyloxy-1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-isoquinoline

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Technology Process of 5-benzyloxy-1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-isoquinoline

There total 10 articles about 5-benzyloxy-1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: N-[2-(2-benzyloxy-3,4-dimethoxy-phenyl)-ethyl]-2-(3,4-dimethoxy-phenyl)-acetamide

: 919082-27-2
5-benzyloxy-1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-isoquinoline

Guidance literature:: With trichlorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1021/jo061810h

Reference yield:

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 919082-27-2
5-benzyloxy-1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-isoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

2: sodium carbonate / dichloromethane; water / 2 h / 20 °C

3: trichlorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C

With oxalyl dichloride; sodium carbonate; N,N-dimethyl-formamide; trichlorophosphate; In dichloromethane; water; N,N-dimethyl-formamide; 3: Bischler-Napieralski reaction;
DOI:10.1021/jo061810h

Reference yield:

: 19283-70-6
3,4-dimethoxysalicylaldehyde

: 919082-27-2
5-benzyloxy-1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-isoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetone / 6 h / Heating

2: acetic acid; ethylenediamine / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 20 °C

4: sodium carbonate / dichloromethane; water / 2 h / 20 °C

5: trichlorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C

With lithium aluminium tetrahydride; sodium carbonate; potassium carbonate; acetic acid; ethylenediamine; trichlorophosphate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone; 2: Knoevenagel reaction / 5: Bischler-Napieralski reaction;
DOI:10.1021/jo061810h