bis(3,5-dimethyl-4-methoxyphenyl)phospine oxide

Base Information

• Chemical Name: bis(3,5-dimethyl-4-methoxyphenyl)phospine oxide
• CAS No.: 122977-45-1
• Molecular Formula: C₁₈H₂₃O₃P
• Molecular Weight: 318.353
• Mol file: 122977-45-1.mol

Synonyms:bis(3,5-dimethyl-4-methoxyphenyl)phospine oxide

Chemical Property of bis(3,5-dimethyl-4-methoxyphenyl)phospine oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of bis(3,5-dimethyl-4-methoxyphenyl)phospine oxide

There total 3 articles about bis(3,5-dimethyl-4-methoxyphenyl)phospine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

3,5-dimethyl-4-methoxyphenylmagnesium bromide (185416-17-5) → bis(3,5-dimethyl-4-methoxyphenyl)phospine oxide (122977-45-1)

Guidance literature:

With Diethyl phosphonate; sodium; In tetrahydrofuran; for 1h; Heating;

DOI:10.1021/jo0103930

Reference yield: 63.0%

Diethyl phosphonate (762-04-9,123-22-8) + 5-bromo-2-methoxy-1,3-dimethylbenzene (14804-38-7) → bis(3,5-dimethyl-4-methoxyphenyl)phospine oxide (122977-45-1)

Guidance literature:

With magnesium; In tetrahydrofuran;

DOI:10.1016/S0040-4039(01)80296-3

Reference yield:

4-bromo-2,6-dimethyl-phenol (2374-05-2) → bis(3,5-dimethyl-4-methoxyphenyl)phospine oxide (122977-45-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / NaOH / Bu₄N*I / CH₂Cl₂; H₂O

2: 63 percent / Mg / tetrahydrofuran

With sodium hydroxide; magnesium; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; dichloromethane; water;

DOI:10.1016/S0040-4039(01)80296-3

upstream raw materials:

Diethyl phosphonate

5-bromo-2-methoxy-1,3-dimethylbenzene

3,5-dimethyl-4-methoxyphenylmagnesium bromide

4-bromo-2,6-dimethyl-phenol

Downstream raw materials:

bis(4-methoxy-3,5-dimethylphenyl)-phosphine

Refernces

• 1、 Morimoto, Toshiaki,Chiba, Mitsuo,Achiwa, Kazuo. "HIGHLY EFFICIENT ASYMMETRIC HYDROGENATION OF ITACONIC ACID DERIVATIVES CATALYZED BY A MODIFIED DIOP-RHODIUM COMPLEX". . p. 735 - 738. Retrieved 2007/10/02.