10-(2-methylbenzyl)-2,3,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(10H)-one

Base Information

Chemical Name:10-(2-methylbenzyl)-2,3,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(10H)-one
CAS No.:41642-16-4
Molecular Formula:C₁₇H₂₀N₄O
Molecular Weight:296.372
Hs Code.:

Synonyms:10-(2-methylbenzyl)-2,3,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(10H)-one

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Chemical Property of 10-(2-methylbenzyl)-2,3,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(10H)-one

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Technology Process of 10-(2-methylbenzyl)-2,3,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(10H)-one

There total 5 articles about 10-(2-methylbenzyl)-2,3,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(10H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1616632-79-1
10-(2-methylbenzyl)-2,3-dihydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(10H)-one

: 41642-16-4
10-(2-methylbenzyl)-2,3,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(10H)-one

Guidance literature:: With platinum(IV) oxide; hydrogen; In methanol; trifluoroacetic acid; for 5h;
DOI:10.1002/anie.201402133

Reference yield:

: 1616632-78-0
(4-chloropyridin-3-yl)(2-(methylthio)-4,5-dihydro-1H-imidazol-1-yl)methanone

: 41642-16-4
10-(2-methylbenzyl)-2,3,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(10H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate / N,N-dimethyl acetamide / 1 h / Inert atmosphere; Reflux

2: hydrogen; platinum(IV) oxide / methanol; trifluoroacetic acid / 5 h

With platinum(IV) oxide; potassium phosphate; hydrogen; In methanol; N,N-dimethyl acetamide; trifluoroacetic acid;
DOI:10.1002/anie.201402133

Reference yield:

: 4-chloronicotinic acid chloride hydrochloride

: 41642-16-4
10-(2-methylbenzyl)-2,3,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(10H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 19 h / 0 - 20 °C / Inert atmosphere

2: potassium phosphate / N,N-dimethyl acetamide / 1 h / Inert atmosphere; Reflux

3: hydrogen; platinum(IV) oxide / methanol; trifluoroacetic acid / 5 h

With platinum(IV) oxide; potassium phosphate; hydrogen; triethylamine; In methanol; dichloromethane; N,N-dimethyl acetamide; trifluoroacetic acid;
DOI:10.1002/anie.201402133