(1R,2R,4R,5R)-2,5-bis[(4-methylphenyl)sulfonylamido]bicyclo[2.2.1]heptane

Base Information

Chemical Name:(1R,2R,4R,5R)-2,5-bis[(4-methylphenyl)sulfonylamido]bicyclo[2.2.1]heptane
CAS No.:698353-39-8
Molecular Formula:C₂₁H₂₆N₂O₄S₂
Molecular Weight:434.58
Hs Code.:

Synonyms:(1R,2R,4R,5R)-2,5-bis[(4-methylphenyl)sulfonylamido]bicyclo[2.2.1]heptane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R,4R,5R)-2,5-bis[(4-methylphenyl)sulfonylamido]bicyclo[2.2.1]heptane

Chemical Property:

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Technology Process of (1R,2R,4R,5R)-2,5-bis[(4-methylphenyl)sulfonylamido]bicyclo[2.2.1]heptane

There total 4 articles about (1R,2R,4R,5R)-2,5-bis[(4-methylphenyl)sulfonylamido]bicyclo[2.2.1]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: endo,endo-2,5-bis[(4-methylphenyl)sulfonylamido]bicyclo[2.2.1]heptane

: 698353-39-8
(1R,2R,4R,5R)-2,5-bis[(4-methylphenyl)sulfonylamido]bicyclo[2.2.1]heptane

: 698353-40-1
(1S,2S,4S,5S)-2,5-bis[(4-methylphenyl)sulfonylamido]bicyclo[2.2.1]heptane

Guidance literature:: With Daicel Chiralpak AD column; In hexane; isopropyl alcohol; under 9000.72 Torr;
DOI:10.1021/jo035841d

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 698353-39-8
(1R,2R,4R,5R)-2,5-bis[(4-methylphenyl)sulfonylamido]bicyclo[2.2.1]heptane

Guidance literature:: Multi-step reaction with 2 steps

1: 35 percent / NEt₃ / CH₂Cl₂ / -78 - 20 °C

2: Daicel Chiralpak AD column / hexane; propan-2-ol / 9000.72 Torr

With Daicel Chiralpak AD column; triethylamine; In hexane; dichloromethane; isopropyl alcohol;
DOI:10.1021/jo035841d

Reference yield:

: 141737-16-8
rac-bicyclo[2.2.1]heptane-2,5-dione dioxime

: 698353-39-8
(1R,2R,4R,5R)-2,5-bis[(4-methylphenyl)sulfonylamido]bicyclo[2.2.1]heptane

Guidance literature:: Multi-step reaction with 3 steps

1: NiCl₂; NaBH₄ / methanol / -35 - 20 °C

2: 35 percent / NEt₃ / CH₂Cl₂ / -78 - 20 °C

3: Daicel Chiralpak AD column / hexane; propan-2-ol / 9000.72 Torr

With sodium tetrahydroborate; Daicel Chiralpak AD column; triethylamine; nickel dichloride; In methanol; hexane; dichloromethane; isopropyl alcohol;
DOI:10.1021/jo035841d