(+/-)-2-amino-9-<5'α-<(benzyloxy)methyl>-4'β-(hydroxymethyl)cyclopent-2'-en-1'β-yl>-6-chloropurine

Base Information

Chemical Name:(+/-)-2-amino-9-<5'α-<(benzyloxy)methyl>-4'β-(hydroxymethyl)cyclopent-2'-en-1'β-yl>-6-chloropurine
CAS No.:140440-44-4
Molecular Formula:C₁₉H₂₀ClN₅O₂
Molecular Weight:385.853
Hs Code.:

Synonyms:(+/-)-2-amino-9-<5'α-<(benzyloxy)methyl>-4'β-(hydroxymethyl)cyclopent-2'-en-1'β-yl>-6-chloropurine

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Chemical Property of (+/-)-2-amino-9-<5'α-<(benzyloxy)methyl>-4'β-(hydroxymethyl)cyclopent-2'-en-1'β-yl>-6-chloropurine

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Technology Process of (+/-)-2-amino-9-<5'α-<(benzyloxy)methyl>-4'β-(hydroxymethyl)cyclopent-2'-en-1'β-yl>-6-chloropurine

There total 7 articles about (+/-)-2-amino-9-<5'α-<(benzyloxy)methyl>-4'β-(hydroxymethyl)cyclopent-2'-en-1'β-yl>-6-chloropurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 140440-43-3
(+/-)-2,5-diamino-4-<<5'α-<(benzyloxy)methyl>-4'β-(hydroxymethyl)cyclopent-2'-en-1'β-yl>amino>-6-chloropyridimine

: 122-51-0
orthoformic acid triethyl ester

: 140440-44-4
(+/-)-2-amino-9-<5'α-<(benzyloxy)methyl>-4'β-(hydroxymethyl)cyclopent-2'-en-1'β-yl>-6-chloropurine

Guidance literature:: With hydrogenchloride; for 14h; Ambient temperature;
DOI:10.1021/jm00088a026

Reference yield:

: 140440-35-3
(+/-)-5α-<(benzyloxy)methyl>-4β-(hydroxymethyl)cyclopent-2-en-1β-ylamine

: 140440-44-4
(+/-)-2-amino-9-<5'α-<(benzyloxy)methyl>-4'β-(hydroxymethyl)cyclopent-2'-en-1'β-yl>-6-chloropurine

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / triethylamine / ethanol / 40 h / 100 °C

2: 80 percent / AcONa / H₂O; methanol / 6 h / Ambient temperature

3: 59 percent / Zn, acetic acid / ethanol; H₂O / 3 h / Heating

4: 92 percent / 12N aq. HCl / 14 h / Ambient temperature

With hydrogenchloride; sodium acetate; acetic acid; triethylamine; zinc; In methanol; ethanol; water;
DOI:10.1021/jm00088a026

Reference yield:

: 140440-34-2
ethyl (+/-)-N-<5α-<(benzyloxy)methyl>-4β-(hydroxymethyl)cyclopent-2-en-1β-yl>carbamate

: 140440-44-4
(+/-)-2-amino-9-<5'α-<(benzyloxy)methyl>-4'β-(hydroxymethyl)cyclopent-2'-en-1'β-yl>-6-chloropurine

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / aq. KOH / methanol / 20 h / Heating

2: 80 percent / triethylamine / ethanol / 40 h / 100 °C

3: 80 percent / AcONa / H₂O; methanol / 6 h / Ambient temperature

4: 59 percent / Zn, acetic acid / ethanol; H₂O / 3 h / Heating

5: 92 percent / 12N aq. HCl / 14 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; sodium acetate; acetic acid; triethylamine; zinc; In methanol; ethanol; water;
DOI:10.1021/jm00088a026