2-[3-(3-chloro-4-fluoro-phenyl)-2-(2-methoxycarbonyl-pyrrol-1-yl)-2-methyl-propionyl]-malonic acid benzyl ester methyl ester

Base Information

Chemical Name:2-[3-(3-chloro-4-fluoro-phenyl)-2-(2-methoxycarbonyl-pyrrol-1-yl)-2-methyl-propionyl]-malonic acid benzyl ester methyl ester
CAS No.:1056901-37-1
Molecular Formula:C₂₇H₂₅ClFNO₇
Molecular Weight:529.949
Hs Code.:

Synonyms:2-[3-(3-chloro-4-fluoro-phenyl)-2-(2-methoxycarbonyl-pyrrol-1-yl)-2-methyl-propionyl]-malonic acid benzyl ester methyl ester

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Chemical Property of 2-[3-(3-chloro-4-fluoro-phenyl)-2-(2-methoxycarbonyl-pyrrol-1-yl)-2-methyl-propionyl]-malonic acid benzyl ester methyl ester

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Technology Process of 2-[3-(3-chloro-4-fluoro-phenyl)-2-(2-methoxycarbonyl-pyrrol-1-yl)-2-methyl-propionyl]-malonic acid benzyl ester methyl ester

There total 5 articles about 2-[3-(3-chloro-4-fluoro-phenyl)-2-(2-methoxycarbonyl-pyrrol-1-yl)-2-methyl-propionyl]-malonic acid benzyl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-[1-chlorocarbonyl-2-(3-chloro-4-fluoro-phenyl)-1-methyl-ethyl]-1H-pyrrole-2-carboxylic acid methyl ester

: 52267-39-7
benzyl methyl malonate

: 1056901-37-1
2-[3-(3-chloro-4-fluoro-phenyl)-2-(2-methoxycarbonyl-pyrrol-1-yl)-2-methyl-propionyl]-malonic acid benzyl ester methyl ester

Guidance literature:: benzyl methyl malonate; With sodium hydride; In tetrahydrofuran; at 25 ℃; for 0.333333h;

1-[1-chlorocarbonyl-2-(3-chloro-4-fluoro-phenyl)-1-methyl-ethyl]-1H-pyrrole-2-carboxylic acid methyl ester; In tetrahydrofuran; at 25 ℃; for 16h;

Reference yield:

: 1193-62-0
methyl Pyrrole-2-carboxylate

: 1056901-37-1
2-[3-(3-chloro-4-fluoro-phenyl)-2-(2-methoxycarbonyl-pyrrol-1-yl)-2-methyl-propionyl]-malonic acid benzyl ester methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.53 h

1.2: 0.75 h / 80 °C

2.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.67 h / -78 °C

2.2: 14.03 h / -78 - 25 °C

3.1: trifluoroacetic acid / dichloromethane / 4 h / 25 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 25 °C

5.1: sodium hydride / tetrahydrofuran / 0.33 h / 25 °C

5.2: 16 h / 25 °C

With oxalyl dichloride; potassium hexamethylsilazane; sodium hydride; trifluoroacetic acid; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1056901-35-9
1-[1-carboxy-2-(3-chloro-4-fluoro-phenyl)-1-methyl-ethyl]-1H-pyrrole-2-carboxylic acid methyl ester

: 1056901-37-1
2-[3-(3-chloro-4-fluoro-phenyl)-2-(2-methoxycarbonyl-pyrrol-1-yl)-2-methyl-propionyl]-malonic acid benzyl ester methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 25 °C

2.1: sodium hydride / tetrahydrofuran / 0.33 h / 25 °C

2.2: 16 h / 25 °C

With oxalyl dichloride; sodium hydride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;