2-{3-[(1R,2R)-2-ethoxycarbonyl-2-hydroxy-1-(2-trifluoromethyl-benzyl)-ethylcarbamoyl]-propyl}-benzoic acid

Base Information

Chemical Name:2-{3-[(1R,2R)-2-ethoxycarbonyl-2-hydroxy-1-(2-trifluoromethyl-benzyl)-ethylcarbamoyl]-propyl}-benzoic acid
CAS No.:1415482-18-6
Molecular Formula:C₂₄H₂₆F₃NO₆
Molecular Weight:481.469
Hs Code.:

Synonyms:2-{3-[(1R,2R)-2-ethoxycarbonyl-2-hydroxy-1-(2-trifluoromethyl-benzyl)-ethylcarbamoyl]-propyl}-benzoic acid

Suppliers and Price of 2-{3-[(1R,2R)-2-ethoxycarbonyl-2-hydroxy-1-(2-trifluoromethyl-benzyl)-ethylcarbamoyl]-propyl}-benzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-{3-[(1R,2R)-2-ethoxycarbonyl-2-hydroxy-1-(2-trifluoromethyl-benzyl)-ethylcarbamoyl]-propyl}-benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-{3-[(1R,2R)-2-ethoxycarbonyl-2-hydroxy-1-(2-trifluoromethyl-benzyl)-ethylcarbamoyl]-propyl}-benzoic acid

There total 5 articles about 2-{3-[(1R,2R)-2-ethoxycarbonyl-2-hydroxy-1-(2-trifluoromethyl-benzyl)-ethylcarbamoyl]-propyl}-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415312-38-7
(2R,3R)-3-Amino-2-hydroxy-4-(2-trifluoromethyl-phenyl)-butyric acid ethyl ester

: 1081-27-2
4-(2-carboxy-phenyl)-butyric acid

: 1415482-18-6
2-{3-[(1R,2R)-2-ethoxycarbonyl-2-hydroxy-1-(2-trifluoromethyl-benzyl)-ethylcarbamoyl]-propyl}-benzoic acid

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; for 1h;

Reference yield:

: 130930-49-3
(R)-2-amino-3-(2-trifluoromethyl-phenyl)-propionic acid

: 1415482-18-6
2-{3-[(1R,2R)-2-ethoxycarbonyl-2-hydroxy-1-(2-trifluoromethyl-benzyl)-ethylcarbamoyl]-propyl}-benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; water / acetone / 0 °C / pH 8 - 9

1.2: pH 1

1.3: pH 1

2.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / -20 °C

4.1: sodium hydrogensulfite / water; tetrahydrofuran / 0 °C

5.1: hydrogenchloride / 1,4-dioxane / Reflux

5.2: 4 h / Reflux

6.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 1 h

With hydrogenchloride; lithium aluminium tetrahydride; water; benzotriazol-1-ol; sodium hydrogensulfite; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetone;

Reference yield:

: 1177728-27-6
C₁₈H₁₆F₃NO₄

: 1415482-18-6
2-{3-[(1R,2R)-2-ethoxycarbonyl-2-hydroxy-1-(2-trifluoromethyl-benzyl)-ethylcarbamoyl]-propyl}-benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / -20 °C

3.1: sodium hydrogensulfite / water; tetrahydrofuran / 0 °C

4.1: hydrogenchloride / 1,4-dioxane / Reflux

4.2: 4 h / Reflux

5.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 1 h

With hydrogenchloride; lithium aluminium tetrahydride; benzotriazol-1-ol; sodium hydrogensulfite; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;