4-{7-[3-cyano-4-(tetrahydropyran-4-yloxy)phenyl]furo[3,2-b]pyridin-2-yl}-2-methoxybenzoic acid methyl ester

Base Information

Chemical Name:4-{7-[3-cyano-4-(tetrahydropyran-4-yloxy)phenyl]furo[3,2-b]pyridin-2-yl}-2-methoxybenzoic acid methyl ester
CAS No.:1449709-82-3
Molecular Formula:C₂₈H₂₄N₂O₆
Molecular Weight:484.508
Hs Code.:

Synonyms:4-{7-[3-cyano-4-(tetrahydropyran-4-yloxy)phenyl]furo[3,2-b]pyridin-2-yl}-2-methoxybenzoic acid methyl ester

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Chemical Property of 4-{7-[3-cyano-4-(tetrahydropyran-4-yloxy)phenyl]furo[3,2-b]pyridin-2-yl}-2-methoxybenzoic acid methyl ester

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Technology Process of 4-{7-[3-cyano-4-(tetrahydropyran-4-yloxy)phenyl]furo[3,2-b]pyridin-2-yl}-2-methoxybenzoic acid methyl ester

There total 1 articles about 4-{7-[3-cyano-4-(tetrahydropyran-4-yloxy)phenyl]furo[3,2-b]pyridin-2-yl}-2-methoxybenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1449709-82-3
4-{7-[3-cyano-4-(tetrahydropyran-4-yloxy)phenyl]furo[3,2-b]pyridin-2-yl}-2-methoxybenzoic acid methyl ester

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium carbonate; In 1,4-dioxane; water; at 100 ℃; for 3h; Inert atmosphere;

Reference yield:

: 1449709-82-3
4-{7-[3-cyano-4-(tetrahydropyran-4-yloxy)phenyl]furo[3,2-b]pyridin-2-yl}-2-methoxybenzoic acid methyl ester

: 1449712-49-5
4-{7-[3-cyano-4-(tetrahydropyran-4-yloxy)phenyl]furo[3,2-b]pyridin-2-yl}-2-methoxybenzoic acid

Guidance literature:: With ethanol; sodium hydroxide; at 20 ℃;

Reference yield:

: 1449709-82-3
4-{7-[3-cyano-4-(tetrahydropyran-4-yloxy)phenyl]furo[3,2-b]pyridin-2-yl}-2-methoxybenzoic acid methyl ester

: 1449710-19-3
5-{2-[3-methoxy-4-(2-oxa-6-azaspiro[3.3]heptane-6-carbonyl)phenyl]furo[3,2-b]pyridin-7-yl}-2-(tetrahydropyran-4-yloxy)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol; sodium hydroxide / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-1H-benzotriazol hydrate; 4-methyl-morpholine / dimethyl sulfoxide / 16 h / 20 °C

With 4-methyl-morpholine; ethanol; 1-hydroxy-1H-benzotriazol hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In dimethyl sulfoxide;