Technology Process of (R)-1-phenyl-1-eicosanol
There total 4 articles about (R)-1-phenyl-1-eicosanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Burkholderica cepacia amano lipase;
In
acetone;
at 25 ℃;
pH=7.2;
optical yield given as %ee;
enantioselective reaction;
aq. phosphate buffer;
Enzymatic reaction;
DOI:10.1016/j.tetasy.2011.07.017
- Guidance literature:
-
eicosanophenone;
With
C29H48BO14(1-)*Na(1+);
In
tetrahydrofuran;
at 25 ℃;
With
hydrogenchloride;
In
tetrahydrofuran; water;
optical yield given as %ee;
enantioselective reaction;
DOI:10.1016/j.tetasy.2010.12.010
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0 - 5 °C
2: Amberlist 15 / 0.5 h / 25 °C
3: Burkholderica cepacia amano lipase / acetone / 25 °C / pH 7.2 / aq. phosphate buffer; Enzymatic reaction
With
sodium tetrahydroborate; Burkholderica cepacia amano lipase;
In
tetrahydrofuran; methanol; acetone;
DOI:10.1016/j.tetasy.2011.07.017
