(+)-4-[(αR)-α-[(2S,5R)-4-propargyl-2,5-dimethyl-1-piperazinyl]-3-hydroxybenzyl]-N,N-diethylbenzamide

Base Information

Chemical Name:(+)-4-[(αR)-α-[(2S,5R)-4-propargyl-2,5-dimethyl-1-piperazinyl]-3-hydroxybenzyl]-N,N-diethylbenzamide
CAS No.:214606-87-8
Molecular Formula:C₂₇H₃₅N₃O₂
Molecular Weight:433.594
Hs Code.:

Synonyms:(+)-4-[(αR)-α-[(2S,5R)-4-propargyl-2,5-dimethyl-1-piperazinyl]-3-hydroxybenzyl]-N,N-diethylbenzamide

Suppliers and Price of (+)-4-[(αR)-α-[(2S,5R)-4-propargyl-2,5-dimethyl-1-piperazinyl]-3-hydroxybenzyl]-N,N-diethylbenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (+)-4-[(αR)-α-[(2S,5R)-4-propargyl-2,5-dimethyl-1-piperazinyl]-3-hydroxybenzyl]-N,N-diethylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (+)-4-[(αR)-α-[(2S,5R)-4-propargyl-2,5-dimethyl-1-piperazinyl]-3-hydroxybenzyl]-N,N-diethylbenzamide

There total 1 articles about (+)-4-[(αR)-α-[(2S,5R)-4-propargyl-2,5-dimethyl-1-piperazinyl]-3-hydroxybenzyl]-N,N-diethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 106-96-7
propargyl bromide

: 214606-86-7
(+)-4-[(αR)-α-[(2S,5R)-2,5-dimethyl-1-piperazinyl]-3-hydroxybenzyl]-N,N-diethylbenzamide

: 214606-87-8
(+)-4-[(αR)-α-[(2S,5R)-4-propargyl-2,5-dimethyl-1-piperazinyl]-3-hydroxybenzyl]-N,N-diethylbenzamide

Guidance literature:: With sodium carbonate; In dichloromethane; at 20 ℃; for 20h;
DOI:10.1002/(SICI)1099-1344(1998090)41:9<801::AID-JLCR130>3.0.CO;2-C

Reference yield: 66.0%

: tri-n-butyltin hydride

: 214606-87-8
(+)-4-[(αR)-α-[(2S,5R)-4-propargyl-2,5-dimethyl-1-piperazinyl]-3-hydroxybenzyl]-N,N-diethylbenzamide

: (+)-4-[(αR)-α-[(2S,5R)-4-(tri-n-butyltinpropen-2-yl)-2,5-dimethyl-1-piperazinyl]-3-hydroxybenzyl]-N,N-diethylbenzamide

: 214606-88-9,214606-89-0
(+)-4-[(αR)-α-[(2S,5R)-4-(tri-n-butyltinpropen-2-yl)-2,5-dimethyl-1-piperazinyl]-3-hydroxybenzyl]-N,N-diethylbenzamide

Guidance literature:: In toluene; for 48h; Heating;
DOI:10.1002/(SICI)1099-1344(1998090)41:9<801::AID-JLCR130>3.0.CO;2-C

Reference yield:

: 214606-87-8
(+)-4-[(αR)-α-[(2S,5R)-4-propargyl-2,5-dimethyl-1-piperazinyl]-3-hydroxybenzyl]-N,N-diethylbenzamide

: (+)-4-[(αR)-α-[(2S,5R)-4-(iodopropen-2-yl)-2,5-dimethyl-1-piperazinyl]-3-hydroxybenzyl]-N,N-diethylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / toluene / 48 h / Heating

2: 64 percent / I₂ / CH₂Cl₂ / 0.25 h / 20 °C

With iodine; In dichloromethane; toluene; 1: Metallation / 2: Iodination;
DOI:10.1002/(SICI)1099-1344(1998090)41:9<801::AID-JLCR130>3.0.CO;2-C