5-cyclopropyl-6-(2,2,2-trifluoroethoxy)nicotinic acid N′-(4-fluorophenyl)-N′-methylhydrazide

Base Information

Chemical Name:5-cyclopropyl-6-(2,2,2-trifluoroethoxy)nicotinic acid N′-(4-fluorophenyl)-N′-methylhydrazide
CAS No.:1427064-45-6
Molecular Formula:C₁₈H₁₇F₄N₃O₂
Molecular Weight:383.345
Hs Code.:

Synonyms:5-cyclopropyl-6-(2,2,2-trifluoroethoxy)nicotinic acid N′-(4-fluorophenyl)-N′-methylhydrazide

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Chemical Property of 5-cyclopropyl-6-(2,2,2-trifluoroethoxy)nicotinic acid N′-(4-fluorophenyl)-N′-methylhydrazide

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Technology Process of 5-cyclopropyl-6-(2,2,2-trifluoroethoxy)nicotinic acid N′-(4-fluorophenyl)-N′-methylhydrazide

There total 4 articles about 5-cyclopropyl-6-(2,2,2-trifluoroethoxy)nicotinic acid N′-(4-fluorophenyl)-N′-methylhydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1427064-90-1
5-cyclopropyl-6-(2,2,2-trifluoroethoxy)nicotinic acid

: 1-(4-fluorophenyl)-1-methylhydrazine hydrochloride

: 1427064-45-6
5-cyclopropyl-6-(2,2,2-trifluoroethoxy)nicotinic acid N′-(4-fluorophenyl)-N′-methylhydrazide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1427064-90-1
5-cyclopropyl-6-(2,2,2-trifluoroethoxy)nicotinic acid

: 1-(4-fluorophenyl)-1-methylhydrazine hydrochloride

: 1427064-45-6
5-cyclopropyl-6-(2,2,2-trifluoroethoxy)nicotinic acid N′-(4-fluorophenyl)-N′-methylhydrazide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1427064-89-8
5-cyclopropyl-6-(2,2,2-trifluoroethoxy)nicotinic acid methyl ester

: 1427064-45-6
5-cyclopropyl-6-(2,2,2-trifluoroethoxy)nicotinic acid N′-(4-fluorophenyl)-N′-methylhydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / water; tetrahydrofuran / 21 h / 20 - 40 °C

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; tetrahydrofuran / 20 °C

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;