3-(3-benzyl-1-methyl-5-nitro-1H-pyrazol-4-yl)-N-(tert-butoxycarbonyl)-L-alanine

Base Information

Chemical Name:3-(3-benzyl-1-methyl-5-nitro-1H-pyrazol-4-yl)-N-(tert-butoxycarbonyl)-L-alanine
CAS No.:1380348-01-5
Molecular Formula:C₁₉H₂₄N₄O₆
Molecular Weight:404.423
Hs Code.:

Synonyms:3-(3-benzyl-1-methyl-5-nitro-1H-pyrazol-4-yl)-N-(tert-butoxycarbonyl)-L-alanine

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Chemical Property of 3-(3-benzyl-1-methyl-5-nitro-1H-pyrazol-4-yl)-N-(tert-butoxycarbonyl)-L-alanine

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Technology Process of 3-(3-benzyl-1-methyl-5-nitro-1H-pyrazol-4-yl)-N-(tert-butoxycarbonyl)-L-alanine

There total 9 articles about 3-(3-benzyl-1-methyl-5-nitro-1H-pyrazol-4-yl)-N-(tert-butoxycarbonyl)-L-alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 3-(3-benzyl-1-methyl-5-nitro-1H-pyrazol-4-yl)-L-alanine hydrochloride

: 1380348-01-5
3-(3-benzyl-1-methyl-5-nitro-1H-pyrazol-4-yl)-N-(tert-butoxycarbonyl)-L-alanine

Guidance literature:: With triethylamine; In 1,4-dioxane; water; for 20h;

Reference yield:

: 1380347-98-7
tert-butyl 3-(3-benzyl-1-methyl-5-nitro-1H-pyrazol-4-yl)-N-(diphenylmethylene)-L-alaninate

: 1380348-01-5
3-(3-benzyl-1-methyl-5-nitro-1H-pyrazol-4-yl)-N-(tert-butoxycarbonyl)-L-alanine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / acetonitrile; water / 20 h / 20 °C / Reflux

2: triethylamine / 1,4-dioxane; water / 20 h

With hydrogenchloride; triethylamine; In 1,4-dioxane; water; acetonitrile;

Reference yield:

: 1268522-40-2
5-amino-3-benzyl-1-methyl-1H-pyrazole-4-carboxylic acid

: 1380348-01-5
3-(3-benzyl-1-methyl-5-nitro-1H-pyrazol-4-yl)-N-(tert-butoxycarbonyl)-L-alanine

Guidance literature:: Multi-step reaction with 6 steps

1: sodium nitrite; tetrafluoroboric acid / water

2: dimethylsulfide borane complex / tetrahydrofuran / -20 °C / Reflux

3: carbon tetrabromide; triphenylphosphine / dichloromethane

4: O-allyl-N-(9-anthracenylmethyl)cinchonidinium bromide; cesiumhydroxide monohydrate / dichloromethane / -30 °C

5: trifluoroacetic acid / dichloromethane

6: sodium hydroxide / tetrahydrofuran

With tetrafluoroboric acid; cesiumhydroxide monohydrate; carbon tetrabromide; dimethylsulfide borane complex; O-allyl-N-(9-anthracenylmethyl)cinchonidinium bromide; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; sodium nitrite; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.bmcl.2013.02.039