N-phenylacetyl-N'-[6-(tert-butoxycarbonylamino)hexanoyl]-1,4-diaminobutane

Base Information

Chemical Name:N-phenylacetyl-N'-[6-(tert-butoxycarbonylamino)hexanoyl]-1,4-diaminobutane
CAS No.:327048-70-4
Molecular Formula:C₂₃H₃₇N₃O₄
Molecular Weight:419.564
Hs Code.:

Synonyms:N-phenylacetyl-N'-[6-(tert-butoxycarbonylamino)hexanoyl]-1,4-diaminobutane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-phenylacetyl-N'-[6-(tert-butoxycarbonylamino)hexanoyl]-1,4-diaminobutane

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Technology Process of N-phenylacetyl-N'-[6-(tert-butoxycarbonylamino)hexanoyl]-1,4-diaminobutane

There total 2 articles about N-phenylacetyl-N'-[6-(tert-butoxycarbonylamino)hexanoyl]-1,4-diaminobutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 6404-29-1
6-(tert-butoxycarbonylamino)hexanoic acid

: 327048-69-1
N-phenylacetyl-1,4-diaminobutane

: 327048-70-4
N-phenylacetyl-N'-[6-(tert-butoxycarbonylamino)hexanoyl]-1,4-diaminobutane

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 6.5h;
DOI:10.1021/jm0001525

Reference yield:

: 103-82-2
phenylacetic acid

: 327048-70-4
N-phenylacetyl-N'-[6-(tert-butoxycarbonylamino)hexanoyl]-1,4-diaminobutane

Guidance literature:: Multi-step reaction with 2 steps

1.1: DCC; HOBt / CHCl₃; dimethylformamide / 0.5 h / 20 °C

1.2: 53 percent / CHCl₃; dimethylformamide / 3 h / 20 °C

2.1: 75 percent / HOBt; DIEA; DCC / CH₂Cl₂; dimethylformamide / 6.5 h / 0 - 20 °C

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm0001525