3-Ethyl-5-methyl 1-(4-fluoro-3-cyano)phenyl-4-azidopyrazole-3,5-dicarboxylate

Base Information

Chemical Name:3-Ethyl-5-methyl 1-(4-fluoro-3-cyano)phenyl-4-azidopyrazole-3,5-dicarboxylate
CAS No.:280120-05-0
Molecular Formula:C₁₅H₁₁FN₆O₄
Molecular Weight:358.289
Hs Code.:

Synonyms:3-Ethyl-5-methyl 1-(4-fluoro-3-cyano)phenyl-4-azidopyrazole-3,5-dicarboxylate

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Chemical Property of 3-Ethyl-5-methyl 1-(4-fluoro-3-cyano)phenyl-4-azidopyrazole-3,5-dicarboxylate

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Technology Process of 3-Ethyl-5-methyl 1-(4-fluoro-3-cyano)phenyl-4-azidopyrazole-3,5-dicarboxylate

There total 4 articles about 3-Ethyl-5-methyl 1-(4-fluoro-3-cyano)phenyl-4-azidopyrazole-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 280120-04-9
3-Ethyl-5-methyl 1-(4-fluoro-3-cyano)phenyl-4-aminopyrazole-3,5-dicarboxylate

: 280120-05-0
3-Ethyl-5-methyl 1-(4-fluoro-3-cyano)phenyl-4-azidopyrazole-3,5-dicarboxylate

Guidance literature:: 3-Ethyl-5-methyl 1-(4-fluoro-3-cyano)phenyl-4-aminopyrazole-3,5-dicarboxylate; With trifluoroacetic acid; sodium nitrite; at 0 ℃;

With sodium azide;
DOI:10.1016/j.bmcl.2006.07.002

Reference yield:

: 17417-09-3
2-fluoro-5-nitrobenzonitrile

: 280120-05-0
3-Ethyl-5-methyl 1-(4-fluoro-3-cyano)phenyl-4-azidopyrazole-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / H₂ / Pd/C / ethanol / 760 Torr

2.1: NaNO₂; aq. HCl / 0 °C

2.2: 55 percent / aq. NaOAc / methanol / 0 °C

3.1: K₂CO₃ / dimethylformamide / 90 °C

4.1: NaNO₂; TFA / 0 °C

4.2: 80 percent / NaN₃

With hydrogenchloride; hydrogen; potassium carbonate; trifluoroacetic acid; sodium nitrite; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.07.002

Reference yield:

: 280120-03-8
cyano-[(3-cyano-4-fluoro-phenyl)-hydrazono]-acetic acid ethyl ester

: 280120-05-0
3-Ethyl-5-methyl 1-(4-fluoro-3-cyano)phenyl-4-azidopyrazole-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: K₂CO₃ / dimethylformamide / 90 °C

2.1: NaNO₂; TFA / 0 °C

2.2: 80 percent / NaN₃

With potassium carbonate; trifluoroacetic acid; sodium nitrite; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.07.002