(1R,2S)-2-(2,6-Dichloro-benzyloxy)-1,2-bis-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethanol

Base Information

Chemical Name:(1R,2S)-2-(2,6-Dichloro-benzyloxy)-1,2-bis-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethanol
CAS No.:189701-49-3
Molecular Formula:C₁₉H₂₆Cl₂O₆
Molecular Weight:421.318
Hs Code.:

Synonyms:(1R,2S)-2-(2,6-Dichloro-benzyloxy)-1,2-bis-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2S)-2-(2,6-Dichloro-benzyloxy)-1,2-bis-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethanol

Chemical Property:

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Technology Process of (1R,2S)-2-(2,6-Dichloro-benzyloxy)-1,2-bis-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethanol

There total 1 articles about (1R,2S)-2-(2,6-Dichloro-benzyloxy)-1,2-bis-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 2014-83-7
1,3-Dichloro-2-chloromethyl-benzene

: 1707-77-3
1,2:5,6-di-O-isopropylidene-D-mannitol

: 189701-49-3
(1R,2S)-2-(2,6-Dichloro-benzyloxy)-1,2-bis-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethanol

: C₂₆H₃₀Cl₄O₆

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; Yields of byproduct given;
DOI:10.1021/jo961542v

Reference yield: 88.0%

: 189701-49-3
(1R,2S)-2-(2,6-Dichloro-benzyloxy)-1,2-bis-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethanol

: 170874-83-6
(R)-2-(2,6-Dichloro-benzyloxy)-1,2-bis-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethanone

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -68 ℃; for 60h;

Reference yield:

: 189701-49-3
(1R,2S)-2-(2,6-Dichloro-benzyloxy)-1,2-bis-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethanol

: (1R,2S)-1-(2,6-Dichloro-benzyloxy)-1,2-bis-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-butan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / oxalyl chloride, DMSO, TEA / CH₂Cl₂ / 1.) -78 deg C, 15 min, 2.) -78 deg C to 0 deg C

2: tetrahydrofuran / 0.25 h / 0 °C

With oxalyl dichloride; TEA; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo961542v